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B6db families:
Description 2-amino-4-oxopentanoate thiolase
Notes A very compact and distinct family of enzymes from eubacteria, related to cysteine synthases (family and Cystathionine beta-synthases (
These sequences represent the beta subunit of the enzyme; in genomic clusters they are constantly accompanied by a smaller alpha subunit (not PLP dependent); e.g. ORTA_UNKP.
PLP Fold Type II
PLP-dependent Domain
Domain alignment
Domain hmm
Fold type II

Number of sequences 14
Sequences in seed alignment
BacteriaKXG78696 (Fervidicola ferrireducens); WP_078695469 (Caloramator quimbayensis); WP_042832903 (Thermoanaerobacter sp. YS13); WP_012447626 (Natranaerobius thermophilus); WP_002541640 (Cutibacterium acnes); YP_001306153 (Thermosipho melanesiensis BI429); WP_098973765 (Fusobacterium nucleatum); WP_012063498 (Alkaliphilus metalliredigens); WP_013361505 ([Clostridium] sticklandii); AJP10139 (Clostridioides difficile 630); WP_012208987 (Petrotoga mobilis SJ95); WP_072865719 (Marinitoga hydrogenitolerans); ORTB_UNKP (unidentified prokaryotic organism); YP_001411136 (Fervidobacterium nodosum Rt17-B1);

DISPLAY: Fasta format, alignment, hmm, hmm_local

Reference sequence ORTB_UNKP
Domain interval 57-370
Catalytic site 102 K
 Fonknechten N1, Perret A, Perchat N, Tricot S, Lechaplais C, Vallenet D, Vergne C, Zaparucha A, Le Paslier D, Weissenbach J, Salanoubat M (2009) A conserved gene cluster rules anaerobic oxidative degradation of L-ornithine J Bacteriol 191 3162-7.

Articles on
last changed 2018/02/14 10:45

B6db families