B6db families : 2_3_1

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2.3.1.37

Activity

2.3.1.37

Description

5-aminolevulinic acid synthase

Notes

A very compact and distinct family of enzymes from eukarya (fungi-metazoa) and eubacteria.
Vertebrates express typically two types of aminolevulinate synthase (encoded by different genes): one housekeeping and the other erythroid-specific.

PDB

2BWP;5TXT;

PLP Fold Type

PLP-dependent Domain

Domain alignment
Domain hmm

Fold type I

Number of sequences

Sequences in seed alignment

Bacteria	ZP_00303686 (Novosphingobium aromaticivorans); D87417 (Caulobacter crescentus); AAR83718 (Rhodopseudomonas palustris); HEM1_RHOCA (Rhodobacter capsulatus); AAX98209 (Streptomyces aizunensis); HEM1_RHOSH (Rhodobacter sphaeroides); SKA31381 (Marinactinospora thermotolerans DSM 45154); HEM1_BRAJA (Bradyrhizobium japonicum); ABD39319 (Agrobacterium tumefaciens (radiobacter)); AF3452 (Brucella melitensis); AAO62615 (Streptomyces nodosus subsp. asukaensis); KDN87766 (Kitasatospora cheerisanensis KCTC 2395); HEM0_RHOSH (Rhodobacter sphaeroides); HEM1_PARDE (Paracoccus denitrificans); HEM1_RHIME (Rhizobium meliloti); AFU07636 (Rhodopseudomonas palustris);
Fungi	HEM1_EMENI (Emericella nidulans); AAD38391 (Aspergillus oryzae); HEM1_YEAST (Saccharomyces cerevisiae); HEM1_KLULA (Kluyveromyces lactis); HEM1_CANAL (Candida albicans); HEM1_AGABI (Agaricus bisporus);
Metazoa	HEM1_OPSTA (Opsanus tau); HEM0_BRARE (Danio rerio); HEM0_RAT (Rattus norvegicus); AD20807 (Glycera dibranchiata); HEM0_HUMAN (Homo sapiens); AAD20808 (Sepia officinalis); CAA74915 (Drosophila melanogaster); HEM0_OPSTA (Opsanus tau); HEM0_MOUSE (Mus musculus); HEM1_CHICK (Gallus gallus); HEM1_RAT (Rattus norvegicus); HEM1_HUMAN (Homo sapiens); HEM0_CHICK (Gallus gallus);
Other_Eukarya	XP_001350846 (Plasmodium falciparum 3D7); CEM21130 (Vitrella brassicaformis CCMP3155); SGX80493 (Plasmodium vivax);

DISPLAY: Fasta format, alignment, hmm, hmm_local

Reference sequence

HEM0_MOUSE

Domain interval

189-536

Catalytic site

391 K

References

Brown BL, Kardon JR, Sauer RT, Baker TA (2018) Structure of the Mitochondrial Aminolevulinic Acid Synthase, a Key Heme Biosynthetic Enzyme Structure 26 580-589.

Hanh NPK, Hwang JY, Oh HR, Kim GJ, Choi H, Nam DH (2018) Biosynthesis of 2-amino-3-hydroxycyclopent-2-enone moiety of bafilomycin in Kitasatospora cheerisanensis KCTC2395. 2 J Microbiol 56 571-578.

Bishop DF, Tchaikovskii V, Nazarenko I, Desnick RJ (2013) Molecular expression and characterization of erythroid-specific 5-aminolevulinate synthase gain-of-function mutations causing X-linked protoporphyria Mol Med 5 18-25.

Zhang L, Chen J, Chen N, Sun J, Zheng P, Ma Y. (2013) Cloning of two 5-aminolevulinic acid synthase isozymes HemA and HemO from Rhodopseudomonas palustris with favorable characteristics for 5-aminolevulinic acid production Biotechnol Lett 35 763-8.

Zhang W, Bolla ML, Kahne D, Walsh CT. (2010) A three enzyme pathway for 2-amino-3-hydroxycyclopent-2-enone formation and incorporation in natural product biosynthesis J Am Chem Soc 132 6402-11.

Lin J, Fu W, Cen P (2009) Characterization of 5-aminolevulinate synthase from Agrobacterium radiobacter, screening new inhibitors for 5-aminolevulinate dehydratase from Escherichia coli and their potential use for high 5-aminolevulinate production Bioresour Technol 100 2293-7.

Petrícek M, Petrícková K, Havlícek L, Felsberg J (2006) Occurrence of two 5-aminolevulinate biosynthetic pathways in Streptomyces nodosus subsp. asukaensis is linked with the production of asukamycin J Bacteriol 188 5113-23.

Astner I, Schulze JO, van den Heuvel J, Jahn D, Schubert WD, Heinz DW. (2005) Crystal structure of 5-aminolevulinate synthase, the first enzyme of heme biosynthesis, and its link to XLSA in humans EMBO J 24 3166-77.

Varadharajan S, Dhanasekaran S, Bonday ZQ, Rangarajan PN, Padmanaban G (2002) Involvement of delta-aminolaevulinate synthase encoded by the parasite gene in de novo haem synthesis by Plasmodium falciparum Biochem J 367 321-7.

Elrod, S.L.; Jones, A.; Berka, R.M.; Cherry, J.R. (2000) Cloning of the Aspergillus oryzae 5-aminolevulinate synthase gene and its use as a selectable marker Curr Genet 38 291-98.

Bolt, E. L.; Kryszak, L.; Zeilstra-Ryalls, J.; Shoolingin-Jordan, P. M.; Warren, M. J. (1999) Characterization of the rhodobacter sphaeroides 5-aminolaevulinic acid synthase isoenzymes, HemA and HemT, isolated from recombinant Escherichia coli Eur J Biochem 265 290-9.

Ferreira, G. C.; Dailey, H. A. (1993) Expression of mammalian 5-aminolevulinate synthase in Escherichia coli. Overproduction, purification, and characterization J Biol Chem 268 584-90.

Articles on 2.3.1.37

last changed

2018/05/07 09:12