B6db families : 2_3_1

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2.3.1.47

Activity

2.3.1.47

Description

8-amino-7-oxononanoate synthase.

Notes

A family constructed based on validated bacterial and plant sequences.
The proteins in this family show a strict phylogenetic relationship to those in family 2.3.1.29 (glycine acetyltransferase). Additionally, at least some of the validated enzymes in the family also show a glycine acetyltransferase activity.

PDB

1DJE;1DJ9;1BS0;

PLP Fold Type

PLP-dependent Domain

Domain alignment
Domain hmm

Fold type I

Number of sequences

Sequences in seed alignment

Bacteria

NP_455337 (Salmonella enterica); NP_404761 (Yersinia pestis); NP_625531 (Streptomyces coelicolor); ZP_00090882 (Azotobacter vinelandii); NP_904050 (Chromobacterium violaceum); BIOF_ERWHE (Erwinia herbicola); ZP_02169770 (Bacillus selenitireducens MLS10); ZP_01462606 (Stigmatella aurantiaca); ZP_00314057 (Clostridium thermocellum); BAB39461 (Kurthia sp.); YP_482841 (Frankia sp. CcI3); NP_777891 (Buchnera aphidicola); ZP_01088761 (Blastopirellula marina); BAB07626 (Bacillus halodurans); NP_797493 (Vibrio parahaemolyticus); YP_528607 (Saccharophagus degradans); YP_001019727 (Methylibium petroleiphilum PM1); CAG20713 (Photobacterium profundum); YP_144848 (Thermus thermophilus HB8); CAE49913 (Corynebacterium diphtheriae); CAE55406 (Mycobacterium tuberculosis H37Rv); BIOF_BACSU (Bacillus subtilis); ZP_00238882 (Bacillus cereus); BIOF_ECOLI (Escherichia coli); AAQ00666 (Prochlorococcus marinus); BIOF_BACSH (Bacillus sphaericus);

Viridiplantae

AAY82238 (Arabidopsis thaliana); CAO45009 (Vitis vinifera); NP_001044174 (Oryza sativa); EDQ65436 (Physcomitrella patens);

DISPLAY: Fasta format, alignment, hmm, hmm_local

Reference sequence

BIOF_ECOLI

Domain interval

39-380

Catalytic site

236 K

References

Kubota T, Shimono J, Kanameda C, Izumi Y. (2007) The first Thermophilic alpha-oxoamine synthase family enzyme that has activities of 2-amino-3-ketobutyrate CoA ligase and 7-keto-8-aminopelargonic acid synthase: Cloning and overexpression of the gene from an extreme thermophile, Thermus thermophilus, and characterization of its gene product Biosci Biotechnol Biochem 23 3033-3040.

Bhor VM, Dev S, Vasanthakumar GR, Kumar P, Sinha S, Surolia A. (2006) Broad substrate stereospecificity of the Mycobacterium tuberculosis 7-keto-8-aminopelargonic acid synthase: Spectroscopic and kinetic studies J Biol Chem 281 25076-88.

Pinon V, Ravanel S, Douce R, Alban C. (2005) Biotin synthesis in plants. The first committed step of the pathway is catalyzed by a cytosolic 7-keto-8-aminopelargonic acid synthase Plant Physiol 139 1666-76.

Alexeev, D.; Alexeeva, M.; Baxter, R. L.; Campopiano, D. J.; Webster, S. P.; Sawyer, L. (1998) The crystal structure of 8-amino-7-oxononanoate synthase: a bacterial PLP-dependent, acyl-CoA-condensing enzyme J Mol Biol 284 401-19.

Ploux, O.; Marquet, A. (1992) The 8-amino-7-oxopelargonate synthase from Bacillus sphaericus. Purification and preliminary characterization of the cloned enzyme overproduced in Escherichia coli Biochem J 283 327-31.

Articles on 2.3.1.47

last changed

2008/01/17 18:30