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2.3.1.47 |
Activity |
2.3.1.47 |
Description |
8-amino-7-oxononanoate synthase |
Notes |
A family constructed based on validated bacterial and plant sequences. The proteins in this family show a strict phylogenetic relationship to those in family 2.3.1.29 (glycine acetyltransferase). Additionally, at least some of the validated enzymes in the family also show a glycine acetyltransferase activity. |
PDB |
1DJE;1DJ9;1BS0; |
PLP Fold Type |
I |
PLP-dependent Domain |
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Number of sequences |
37 |
Sequences in seed alignment |
|
Reference sequence |
BIOF_ECOLI |
Domain interval |
39-380 |
Catalytic site |
236 K |
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References |
Ren X, Wang X, Shi H, Zhang X, Chen Z, Malhi KK, Ding C, Yu S (2018) Riemerella anatipestifer AS87_RS09170 gene is responsible for biotin synthesis, bacterial morphology and virulence Sci Rep 8 14645. Kubota T, Izumi Y.
(2012) Detection and characterization of a thermophilic biotin biosynthetic enzyme, 7-keto-8-aminopelargonic acid synthase, from various thermophiles. Biosci Biotechnol Biochem 76 685-90. Kubota T, Shimono J, Kanameda C, Izumi Y.
(2007) The first Thermophilic alpha-oxoamine synthase family enzyme that has activities of 2-amino-3-ketobutyrate CoA ligase and 7-keto-8-aminopelargonic acid synthase: Cloning and overexpression of the gene from an extreme thermophile, Thermus thermophilus, and characterization of its gene product Biosci Biotechnol Biochem 23 3033-3040. Bhor VM, Dev S, Vasanthakumar GR, Kumar P, Sinha S, Surolia A. (2006) Broad substrate stereospecificity of the Mycobacterium tuberculosis 7-keto-8-aminopelargonic acid synthase: Spectroscopic and kinetic studies J Biol Chem 281 25076-88. Pinon V, Ravanel S, Douce R, Alban C. (2005) Biotin synthesis in plants. The first committed step of the pathway is catalyzed by a cytosolic 7-keto-8-aminopelargonic acid synthase Plant Physiol 139 1666-76. Alexeev, D.; Alexeeva, M.; Baxter, R. L.; Campopiano, D. J.; Webster, S. P.; Sawyer, L. (1998) The crystal structure of 8-amino-7-oxononanoate synthase: a bacterial PLP-dependent, acyl-CoA-condensing enzyme J Mol Biol 284 401-19. Ploux, O.; Marquet, A. (1992) The 8-amino-7-oxopelargonate synthase from Bacillus sphaericus. Purification and preliminary characterization of the cloned enzyme overproduced in Escherichia coli Biochem J 283 327-31. Articles on 2.3.1.47 |
last changed |
2008/01/17 18:30 |
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