B6db families : 2_3_1_50

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2.3.1.50 b

Activity

2.3.1.50

Description

Serine C-palmitoyltransferase (family b)

Notes

This family includes the products LCB2 genes.
Proteins in this family are the water-soluble subunits of eukaryotic serine C-palmitoyl transferases and (contrary to LCB1 proteins - family 2.3.1.50_a) they bind PLP.

PLP Fold Type

PLP-dependent Domain

Domain alignment
Domain hmm

Fold type I

Number of sequences

Sequences in seed alignment

Fungi	AAF21252 (Pichia ciferrii); LCB2_SCHPO (Schizosaccharomyces pombe); LCB2_KLULA (Kluyveromyces lactis); AAP47107 (Aspergillus nidulans); LCB2_YEAST (Saccharomyces cerevisiae);
Metazoa	AAH73312 (Xenopus laevis); LCB2_CRIGR (Cricetulus griseus); AAH78234 (Danio rerio); XP_394921 (Apis mellifera); LCB2_MOUSE (Mus musculus); LCB2_HUMAN (Homo sapiens); NP_505065 (Caenorhabditis elegans);
Other_Eukarya	AAO92019 (Leishmania major);
Viridiplantae	BAB03231 (Arabidopsis thaliana); BAC55228 (Lotus corniculatus); BAB90752 (Oryza sativa (japonica cultivar-group)); BAB90753 (Oryza sativa (japonica cultivar-group)); CAB44316 (Solanum tuberosum);

DISPLAY: Fasta format, alignment, hmm, hmm_local

Reference sequence

LCB2_YEAST

Domain interval

155-515

Catalytic site

366 K

References

Han G, Gable K, Yan L, Allen MJ, Wilson WH, Moitra P, Harmon JM, Dunn TM. (2006) Expression of a novel marine viral single-chain serine palmitoyltransferase and construction of yeast and mammalian single-chain chimera J Biol Chem 281 39935-42.

Bae, J.H.; Sohn, J.H.; Park, C.S.; Rhee, J.S.; Choi, E.S. (2003) Integrative transformation system for the metabolic engineering of the sphingoid base-producing yeast Pichia ciferrii Appl Environ Microbiol 69 812-9.

Tamura, K.; Nishiura, H.; Mori, J.; Imai, H. (2000) Cloning and characterization of a cDNA encoding serine palmitoyltransferase in Arabidopsis thaliana Biochem Soc Trans 28 745-7.

Hanada, K.; Hara, T.; Nishijima, M.; Kuge, O.; Dickson, R.C.; Nagiec, M.M. (1997) A mammalian homolog of the yeast LCB1 encodes a component of serine palmitoyltransferase, the enzyme catalyzing the first step in sphingolipid synthesis J Biol Chem 272 32108-14.

Weiss, B.; Stoffel, W. (1997) Human and murine serine-palmitoyl-CoA transferase--cloning, expression and characterization of the key enzyme in sphingolipid synthesis Eur J Biochem 249 239-47.

Nagiec, M.M.; Baltisberger, J.A.; Wells, G.B.; Lester, R.L.; Dickson, R.C. (1994) The LCB2 gene of Saccharomyces and the related LCB1 gene encode subunits of serine palmitoyltransferase, the initial enzyme in sphingolipid synthesis. Proc Natl Acad Sci U S A 91 7899-902.

Articles on 2.3.1.50.b

last changed

2008/05/20 12:02