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B6db families: 2.4.1.1
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2.4.1.1
Activity 2.4.1.1
Description Phosphorylase.
Notes Very distinct family, the only one belonging to fold-type V.
PDB 1GPB;7GPB;1ABB;1AHP;1L5W;1LWN;
PLP Fold Type V
PLP-dependent Domain
Domain alignment
Domain hmm		Fold type V
Number of sequences
41
Sequences in seed alignment
BacteriaPHSG_SYNY3 (Synechocystis sp. (strain PCC 6803)); PHSM_ECOLI (Escherichia coli); BAB11741 (Thermus aquaticus); PHSG_CHLPN (Chlamydia pneumoniae); AAM52219 (Corynebacterium callunae); PHSG_BACSU (Bacillus subtilis); PHSG_HAEIN (Haemophilus influenzae); PHSM_STRPN (Streptococcus pneumoniae); BAA19592 (Geobacillus stearothermophilus); PHSG_AQUAE (Aquifex aeolicus); PHSG_ECOLI (Escherichia coli); PHSG_CHLTR (Chlamydia trachomatis); PHSG_CHLMU (Chlamydia muridarum);
FungiCAD28434 (Aspergillus fumigatus); PHSG_YEAST (Saccharomyces cerevisiae); ABN66962 (Pichia stipitis); XP_363893 (Magnaporthe grisea);
MetazoaPHSG_DROME (Drosophila melanogaster); PHS2_BOVIN (Bos taurus); PHS3_RAT (Rattus norvegicus); PHS2_RAT (Rattus norvegicus); PHS1_RAT (Rattus norvegicus); PHS2_MOUSE (Mus musculus); PHS2_SHEEP (Ovis aries); PHS1_HUMAN (Homo sapiens); PHS2_RABIT (Oryctolagus cuniculus); PHS1_MOUSE (Mus musculus); PHS2_HUMAN (Homo sapiens); PHS3_HUMAN (Homo sapiens);
Other_EukaryaXP_001449904 (Paramecium tetraurelia); XP_001024430 (Tetrahymena thermophila); PHS2_DICDI (Dictyostelium discoideum); PHS1_DICDI (Dictyostelium discoideum);
ViridiplantaePHS2_SOLTU (Solanum tuberosum); PHSL_VICFA (Vicia faba); PHS1_SOLTU (Solanum tuberosum); PHSL_IPOBA (Ipomoea batatas); PHSH_WHEAT (Triticum aestivum); PHSH_ARATH (Arabidopsis thaliana); PHSH_SOLTU (Solanum tuberosum); PHSH_VICFA (Vicia faba);

DISPLAY: Fasta format, alignment, hmm, hmm_local
Reference sequence PHSG_YEAST
Domain interval 164-900
Catalytic site 751 K
 
References
 Schwarz A, Pierfederici FM, Nidetzky B. (2005) Catalytic mechanism of alpha-retaining glucosyl transfer by Corynebacterium callunae starch phosphorylase: the role of histidine-334 examined through kinetic characterization of site-directed mutants. Biochem J 210 437-45.

 Bhuiyan, S.H.; Rus'd, A.A.; Kitaoka, M.; Hayashi, K. (2003) Characterization of a hyperthermostable glycogen phosphorylase from Aquifex aeolicus expressed in Escherichia coli J Mol Catal B: Enzymatic 22 173-80.

 Takaha, T.; Yanase, M.; Takata, H.; Okada, S. (2001) Structure and properties of Thermus aquaticus alpha-glucan phosphorylase expressed in Escherichia coli J. Appl. Glycosci. 48 71-78.

 O'Reilly, M.; Watson, K. A.; Johnson, L. N. (1999) The crystal structure of the Escherichia coli maltodextrin phosphorylase-acarbose complex Biochemistry 38 5337-45.

 Takata, H.; Takaha, T.; Okada, S.; Takagi, M.; Imanaka, T.; (1998) Purification and characterization of alpha-glucan phosphorylase from Bacillus stearothermophilus J. Ferment Bioeng 85 156-161.

 Rath, V. L.; Hwang, P. K.; Fletterick, R. J. (1992) Purification and crystallization of glycogen phosphorylase from Saccharomyces cerevisiae J Mol Biol 225 1027-34.

 Mori, H.; Tanizawa, K.; Fukui, T. (1991) Potato tuber type H phosphorylase isozyme. Molecular cloning, nucleotide sequence, and expression of a full-length cDNA in Escherichia coli J Biol Chem 266 18446-53.

 Sprang SR, Withers SG, Goldsmith EJ, Fletterick RJ, Madsen NB. (1991) Structural basis for the activation of glycogen phosphorylase b by adenosine monophosphate Science 254 1367-1371.

 Titani K, Koide A, Hermann J, Ericsson LH, Kumar S, Wade RD, Walsh KA, Neurath H, Fischer EH. (1977) Complete amino acid sequence of rabbit muscle glycogen phosphorylase. Proc Natl Acad Sci U S A 74 4762-6.

Articles on 2.4.1.1
last changed 2008/04/01 16:56

B6db families