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B6db families:
Description Cystathionine β-synthase (O-acetyl-L-serine)
Notes Family based on the functionally validated sequence from B. anthracis, related to standard CBS and to cysteine synthases.

A distinctive residue of this family is Glu228 (in the B anthracis sequence BAR74765) which is necessary for generating H2S.

PLP Fold Type II
PLP-dependent Domain
Domain alignment
Domain hmm
Fold type II

Number of sequences 13
Sequences in seed alignment
BacteriaKEF36177 (Bacillus azotoformans MEV2011); WP_053417152 (Viridibacillus arvi); P56067 (Helicobacter pylori 26695); BAR74765 (Bacillus anthracis); KLH96784 (Brevibacillus formosus); SFA38476 (Parageobacillus thermantarcticus); WP_003229809 (Bacillus subtilis); CEH27665 (Aneurinibacillus migulanus); WP_003641836 (Lactobacillus plantarum); CUS16280 (Lactobacillus delbrueckii subsp. bulgaricus); WP_053432880 (Sporosarcina globispora); ABQ48285 (Staphylococcus aureus subsp. aureus JH9); EKP89626 (Oenococcus oeni DSM 20252);

DISPLAY: Fasta format, alignment, hmm, hmm_local

Reference sequence BAR74765
Domain interval 15-300
Catalytic site 52 K
 Devi S, Tarique KF, Ali MF, Abdul Rehman SAX, Gourinath S (2019) Identification and characterisation of Helicobacter pylori O-acetylserine-dependent cystathionine β-synthase, a distinct member of the PLP-II family Mol Microbiol 112 718-739.

 Devi S, Abdul Rehman SA, Tarique KF, Gourinath S (2017) Structural characterization and functional analysis of cystathionine β-synthase: an enzyme involved in the reverse transsulfuration pathway of Bacillus anthracis FEBS J 284 3862-3880.

 Matoba Y, Yoshida T, Izuhara-Kihara H, Noda M, Sugiyama M (2017) Crystallographic and mutational analyses of cystathionine β-synthase in the H2 S-synthetic gene cluster in Lactobacillus plantarum Protein Sci 26 763-783.

 Hullo MF, Auger S, Soutourina O, Barzu O, Yvon M, Danchin A, Martin-Verstraete I (2007) Conversion of methionine to cysteine in Bacillus subtilis and its regulation J Bacteriol 189 187-97.

Articles on
last changed 2019/06/03 10:58

B6db families