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2.6.1.105 |
Activity |
2.6.1.105 |
Description |
Lysine--8-amino-7-oxononanoate transaminase |
Notes |
Family based on the validat3ed sequence from Bacillus subtilis. Enzymes very similar to those in family 2.6.1.62, but distinct based on the fact that use L-lysine as the amino group donor. |
PDB |
3DOD; |
PLP Fold Type |
I |
PLP-dependent Domain |
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Number of sequences |
12 |
Sequences in seed alignment |
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Reference sequence |
BAC03240 |
Domain interval |
29-380 |
Catalytic site |
280 K |
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References |
Dey, S.; Lane, J.M.; Lee, R.E.; Rubin, E.J.; Sacchettini, J.C. (2010) Structural characterization of the Mycobacterium tuberculosis biotin biosynthesis enzymes 7,8-diaminopelargonic acid synthase and dethiobiotin synthetase Biochemistry 49 6746-60. Van Arsdell, SW.; Perkins, J.B.; Yocum, R.R.; Luan, L.; Howitt, C.L.; Prasad Chatterjee, N.; Pero, J.G. (2005) Removing a bottleneck in the Bacillus subtilis biotin pathway: bioA utilizes lysine rather than S-adenosylmethionine as the amino donor in the KAPA-to-DAPA reaction Biotechnol Bioeng 91 75-83. Articles on 2.6.1.105 |
last changed |
2017/09/05 10:02 |
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