B6db families : 2_6_1

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2.6.1.11

Activity

2.6.1.11

Description

Acetylornithine aminotransferase.

Notes

The E. coli enzyme exhibits also succinyldiaminopimelate aminotransferase activity (2.6.1.17), and shows similar specificity constants for N-acetylornithine and N-succinyldiaminopimelate.

PDB

1VEF;2PB0;

PLP Fold Type

PLP-dependent Domain

Domain alignment
Domain hmm

Fold type I

Number of sequences

Sequences in seed alignment

Bacteria	ARGD_STRCL (Streptomyces clavuligerus); ARGD_BUCAI (Buchnera aphidicola (subsp. Acyrthosiphon pisum)); ARGD_LACLA (Lactococcus lactis); ARGD_CORGL (Corynebacterium glutamicum); ARGD_THET2 (Thermus thermophilus Hb8); ZP_00019702 (Chloroflexus aurantiacus); ZP_00032741 (Burkholderia fungorum); ARGD_XYLFT (Xylella fastidiosa); ARGD_SALTY (Salmonella typhimurium); ARGD_LACPL (Lactobacillus plantarum); ARGD_BACSU (Bacillus subtilis); ARGD_THEMA (Thermotoga maritima); BAC88488 (Gloeobacter violaceus); ARGD_XANCP (Xanthomonas campestris); ARGD_ECOLI (Escherichia coli); ARGD_LISIN (Listeria innocua);
Fungi	ARGD_YEAST (Saccharomyces cerevisiae); CAA20713 (Schizosaccharomyces pombe); EAA34262 (Neurospora crassa); EFW96733 (Pichia angusta); ARGD_KLULA (Kluyveromyces lactis);
Viridiplantae	ACD87738 (Chlamydomonas reinhardtii); AAM63124 (Arabidopsis thaliana); ARGD_ALNGL (Alnus glutinosa);

DISPLAY: Fasta format, alignment, hmm, hmm_local

Reference sequence

ARGD_THET2

Domain interval

27-348

Catalytic site

254 K

References

Remacle C, Cline S, Boutaffala L, Gabilly S, Larosa V, Barbieri MR, Coosemans N, Hamel PP. (2009) The ARG9 gene encodes the plastid-resident N-acetyl ornithine aminotransferase in the green alga Chlamydomonas reinhardtii Eukaryot Cell 8 1460-3.

Rajaram V, Ratna Prasuna P, Savithri HS, Murthy MR. (2008) Structure of biosynthetic N-acetylornithine aminotransferase from Salmonella typhimurium: studies on substrate specificity and inhibitor binding Proteins 70 429-41.

Hirotsu K, Goto M, Okamoto A, Miyahara I. (2005) Dual substrate recognition of aminotransferases Chem Rec 5 160-72.

Ledwidge, R.; Blanchard, J.S. (1999) The dual biosynthetic capability of N-acetylornithine aminotransferase in arginine and lysine biosynthesis. Biochemistry 38 3019-24.

Heimberg, H.; Boyen, A.; Crabeel, M.; Glansdorff, N. (1990) Escherichia coli and Saccharomyces cerevisiae acetylornithine aminotransferase: evolutionary relationship with ornithine aminotransferase Gene 90 69-78.

Articles on 2.6.1.11

last changed

2011/03/03 19:16