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B6db families: a
Description Beta-alanine--pyruvate aminotransferase (family a)
Notes The bacterial enzymes in this family are very similar to plant gamma-aminobutyrate--pyruvate aminotransferase (, distinct from EC, which uses preferentially 2-oxoglutarate as an amino group acceptor) and to (putrescine--pyruvate aminotransferase).

A sequence of "beta-alanine-pyruvate aminotransferase from rat" (accession n. BAA19549) is present in NCBI, but the sequence is essentially identical to that of mitochondrial alanine-glyoxylate aminotransferase 2 (

PLP Fold Type I
PLP-dependent Domain
Domain alignment
Domain hmm
Fold type I

Number of sequences 17
Sequences in seed alignment
BacteriaKES23458 (Pseudomonas sp. AAC); CAE43424 (Bordetella pertussis); BAC07960 (Thermosynechococcus elongatus BP-1); AAK25105 (Caulobacter crescentus CB15); AAP92672 (Achromobacter denitrificans); NP_103175 (Mesorhizobium loti); YP_582360 (Ralstonia metallidurans); ZP_00088942 (Azotobacter vinelandii); CAC46983 (Sinorhizobium meliloti); ZP_00015182 (Rhodospirillum rubrum); YP_346418 (Pseudomonas fluorescens); NP_929517 (Photorhabdus luminescens); OAPT_PSEPU (Pseudomonas putida); CAD18207 (Ralstonia solanacearum); AAG03522 (Pseudomonas aeruginosa PA01); ZP_00125337 (Pseudomonas syringae pv. syringae B728a); AAQ59111 (Chromobacterium violaceum);

DISPLAY: Fasta format, alignment, hmm, hmm_local

Reference sequence OAPT_PSEPU
Domain interval 35-390
Catalytic site 288 K
 Wilding M, Peat TS, Newman J, Scott C (2016) A β-Alanine Catabolism Pathway Containing a Highly Promiscuous ω-Transaminase in the 12-Aminododecanate-Degrading Pseudomonas sp. Strain AAC Appl Environ Microbiol 82 3846-56.

 Yun, H.; Lim, S.; Cho, B.K.; Kim, B.G. (2004) omega-Amino acid:pyruvate transaminase from Alcaligenes denitrificans Y2k-2: a new catalyst for kinetic resolution of beta-amino acids and amines Appl Environ Microbiol 70 2529-34.

 Yonaha, K.; Nishie, M.; Aibara, S. (1992) The primary structure of omega-amino acid:pyruvate aminotransferase J Biol Chem 267 12506-10.

 Watanabe, N. Sakabe, K. Sakabe, N. Higashi, T. Sasaki, K. Aibara, S. Morita, Y. Yonaha, K. Toyama, S. Fukutani, H. (1989) Crystal structure analysis of omega-amino acid:pyruvate aminotransferase with a newly developed Weissenberg camera and an imaging plate using synchrotron radiation J Biochem 105 1-3.

Articles on
last changed 2020/02/17 12:14

B6db families