B6db families : 2_6_1_19

	Activities \| Families \| Sequences \| Fold types \| References \| Help

2.6.1.19 a

Activity

2.6.1.19

Description

4-aminobutyrate aminotransferase (family a)

Notes

This subfamily includes metazoan and fungal enzymes. The enzyme from rat liver seems to be identical to (S)-3-amino-2-methylpropanoate aminotransferase (2.6.1.22).

PDB

1OHV;

PLP Fold Type

PLP-dependent Domain

Domain alignment
Domain hmm

Fold type I

Number of sequences

Sequences in seed alignment

Fungi	ABF58894 (Lachancea kluyveri); GATA_YEAST (Saccharomyces cerevisiae); GATA_SCHPO (Schizosaccharomyces pombe); GATA_EMENI (Emericella nidulans); GATA_USTMA (Ustilago maydis); AAG17665 (Cladosporium fulvum);
Metazoa	GABT_RAT (Rattus norvegicus); GABT_BOVIN (Bos taurus); GABT_HUMAN (Homo sapiens); AAH60364 (Xenopus laevis); AAF49081 (Drosophila melanogaster); XP_308791 (Anopheles gambiae); GABT_PIG (Sus scrofa); GABT_CAEEL (Caenorhabditis elegans);

DISPLAY: Fasta format, alignment, hmm, hmm_local

Reference sequence

GABT_RAT

Domain interval

76-446

Catalytic site

357 K

References

Andersen G, Andersen B, Dobritzsch D, Schnackerz KD, Piskur J. (2007) A gene duplication led to specialized gamma-aminobutyrate and beta-alanine aminotransferase in yeast FEBS J 274 1804-17.

Jeon, S.G.; Bahn, J.H.; Jang, J.S.; Jang, S.H.; Lee, B.R.; Lee, K.S.; Park, J.; Kang, T.C.; Won, M.H.; Kim, H.B.; Kwo, O.S.; Cho, S.W.; Choi, S.Y. (2001) Molecular cloning and functional expression of bovine brain GABA transaminase Mol Cells 12 91-6.

Storici, P.; Capitani, G.; De Biase, D.; Moser, M.; John, R. A.; Jansonius, J. N.; Schirmer, T. (1999) Crystal structure of GABA-aminotransferase, a target for antiepileptic drug therapy Biochemistry 38 8628-34.

Medina-Kauwe, L.K.; Tillakaratne, N.J.; Wu, J.Y.; Tobin, A.J. (1994) A rat brain cDNA encodes enzymatically active GABA transaminase and provides a molecular probe for GABA-catabolizing cells J Neurochem 62 1267-75.

Tamaki, N.; Fujimoto, S.; Mizota, C.; Kikugawa, M. (1987) Identity of beta-alanine-oxo-glutarate aminotransferase and L-beta- aminoisobutyrate aminotransferase in rat liver Biochim Biophys Acta 925 238-40.

Articles on 2.6.1.19.a

last changed

2007/10/30 14:51