Activities | Families | Sequences | Fold types | References | Help
B6db families: 2.6.1.1.f

2.6.1.1 f
Activity 2.6.1.1
Description Aspartate aminotransferase (family f)
Notes This family is based on a single validated sequence and includes enzymes from Gram+ bacteria (mostly Bacillaceae).
Sequences here are most strictly related to those in family 2.6.1.1b, yet they are so divergent (and presumably distinct in biological role) that they deserve to be included in a separate family.

The structure of the enzyme from S. aureus has been solved, but apparently its activity has not been testes experimentally.

PDB 2X5F;
PLP Fold Type I
PLP-dependent Domain
Domain alignment
Domain hmm
Fold type I

Reference sequence AAL10665
Domain interval 59-421
Catalytic site 270 K
 
References
 Wu HJ, Yang Y, Wang S, Qiao JQ, Xia YF, Wang Y, Wang WD, Gao SF, Liu J, Xue PQ, Gao XW. (2011) Cloning, expression and characterization of a new aspartate aminotransferase from Bacillus subtilis B3 FEBS J. 278 1345-57.

 Seetharamappa J, Oke M, Liu H, McMahon SA, Johnson KA, Carter L, Dorward M, Zawadzki M, Overton IM, van Niekirk CA, Graham S, Botting CH, Taylor GL, White MF, Barton GJ, Coote PJ, Naismith JH (2007) Expression, purification, crystallization, data collection and preliminary biochemical characterization of methicillin-resistant Staphylococcus aureus Sar2028, an aspartate/tyrosine/phenylalanine pyridoxal-5'-phosphate-dependent aminotransferase Acta Crystallogr Sect F Struct Biol Cryst Commun 63 452-6.

Articles on 2.6.1.1.f
last changed 2019/08/22 12:41

B6db families