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B6db families: f
Description Aspartate aminotransferase (family f)
Notes This family is based on a single validated sequence and includes enzymes from Gram+ bacteria (mostly Bacillaceae).
Sequences here are most strictly related to those in family, yet they are so divergent (and presumably distinct in biological role) that they deserve to be included in a separate family.

The structure of the enzyme from S. aureus has been solved, but apparently its activity has not been testes experimentally.

PLP Fold Type I
PLP-dependent Domain
Domain alignment
Domain hmm
Fold type I

Number of sequences 12
Sequences in seed alignment
BacteriaWP_001068528 (Staphylococcus aureus); WP_019119482 (Brevibacillus massiliensis); PMP71612 (Calditerrivibrio nitroreducens); WP_079558083 (Alkalitalea saponilacus); WP_026840949 (Geobacter bremensis); WP_015254061 (Thermobacillus composti); WP_023483330 (Paenibacillus larvae); KMQ51990 (Chitinispirillum alkaliphilum); AAL10665 (Bacillus subtilis); WP_010287371 (Kurthia massiliensis); WP_025730802 (Bacillus ginsengihumi); WP_048624062 (Bacillus smithii);

DISPLAY: Fasta format, alignment, hmm, hmm_local

Reference sequence AAL10665
Domain interval 59-421
Catalytic site 270 K
 Wu HJ, Yang Y, Wang S, Qiao JQ, Xia YF, Wang Y, Wang WD, Gao SF, Liu J, Xue PQ, Gao XW. (2011) Cloning, expression and characterization of a new aspartate aminotransferase from Bacillus subtilis B3 FEBS J. 278 1345-57.

 Seetharamappa J, Oke M, Liu H, McMahon SA, Johnson KA, Carter L, Dorward M, Zawadzki M, Overton IM, van Niekirk CA, Graham S, Botting CH, Taylor GL, White MF, Barton GJ, Coote PJ, Naismith JH (2007) Expression, purification, crystallization, data collection and preliminary biochemical characterization of methicillin-resistant Staphylococcus aureus Sar2028, an aspartate/tyrosine/phenylalanine pyridoxal-5'-phosphate-dependent aminotransferase Acta Crystallogr Sect F Struct Biol Cryst Commun 63 452-6.

Articles on
last changed 2019/08/22 12:41

B6db families