B6db families : 2_6_1

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2.6.1.30

Activity

2.6.1.30

Description

Pyridoxamine--pyruvate transaminase

Notes

This family is based on a single functionally validated sequence from Mesorhizobium.
These enzymes, despite not being strictly speaking B6-dependent (pyridoxal is a product rather than a cofactor) possess a Fold-type I structure, most similar to that of serine--pyruvate aminotransferase (2.6.1.51).

PDB

2Z9X;

PLP Fold Type

PLP-dependent Domain

Domain alignment
Domain hmm

Fold type I

Number of sequences

Sequences in seed alignment

Bacteria

WP_051562076 (Dongia sp. URHE0060); SFJ14197 (Celeribacter neptunius); WP_036639923 (Paenirhodobacter enshiensis); WP_066706618 (Celeribacter ethanolicus); Q988B8 (Mesorhizobium loti MAFF303099); WP_024900125 (Ochrobactrum rhizosphaerae); WP_037209064 (Rhodovulum sp. NI22); WP_073628838 (Pseudoxanthobacter soli); WP_018063460 (Martelella mediterranea); WP_017800801 (Erwinia toletana); WP_037455754 (Skermanella stibiiresistens);

DISPLAY: Fasta format, alignment, hmm, hmm_local

Reference sequence

Q988B8

Domain interval

42-352

Catalytic site

197 K

References

Yoshikane Y, Yokochi N, Yamasaki M, Mizutani K, Ohnishi K, Mikami B, Hayashi H, Yagi T (2008) Crystal structure of pyridoxamine-pyruvate aminotransferase from Mesorhizobium loti MAFF303099 J Biol Chem 283 1120-7.

Yoshikane Y, Yokochi N, Ohnishi K, Hayashi H, Yagi T (2006) Molecular cloning, expression and characterization of pyridoxamine-pyruvate aminotransferase Biochem J 396 499-507.

Articles on 2.6.1.30

last changed

2017/12/13 13:11