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B6db families: 2.6.1.33.a

2.6.1.33 a
Activity 2.6.1.33
Description dTDP-4-amino-4,6-dideoxy-D-glucose aminotransferase (family a)
Notes The enzyme CalS13 catalyzes the 5'-pyridoxal phosphate (PLP)-dependent stereo- and regiospecific- installation of an amino group from an amino acid donor (typically L-Glu or L-Gln) to the substrate TDP-4-keto-6-deoxy-glucose. CalS13 and the enzyme from E. coli WecE (family 2.6.1.33_a) share common substrates but differ in the stereochemistry of C-4 amine installation. CalS13 provides the C-4 (S) configuration , in contrast, WecE provides the corresponding C-4 (R) configuration.

Sequences in this family are most closely related to dTDP-4-amino-2,4-dideoxy-α-D-xylose transaminases (AtmS13).

PDB 4ZAS;
PLP Fold Type I
PLP-dependent Domain
Domain alignment
Domain hmm
Fold type I

Number of sequences 0
Reference sequence AAM94797
Domain interval 9-373
Catalytic site 194 K
 
References Articles on 2.6.1.33.a
last changed 2019/06/18 13:42

B6db families