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|
2.6.1.33 b |
Activity |
2.6.1.33 |
Description |
dTDP-4-amino-4,6-dideoxy-D-glucose aminotransferase (family b) |
Notes |
A rather heterogeneous family based on the validated enzymes from Escherichia coli O7, Shigella dysenteriae Type 7 and Streptomyces sp.
The family is related to other aminotransferases involved in aminosugar metabolism (2.6.1.87 , 2.6.1.106) and to perosamine aminotransferase. |
PDB |
2PO3;3JU7; |
PLP Fold Type |
I |
PLP-dependent Domain |
|
Number of sequences |
23 |
Sequences in seed alignment |
|
Reference sequence |
AAD44154 |
Domain interval |
14-368 |
Catalytic site |
186 K |
| |
References |
Brown HA, Vinogradov E, Gilbert M, Holden HM (2018) The Mycobacterium tuberculosis Complex has a Pathway for the
Biosynthesis of 4-Formamido-4,6-Dideoxy-D-Glucose Protein Science 27 1491-1497. Dong S, McPherson SA, Wang Y, Li M, Wang P, Turnbough CL Jr, Pritchard DG. (2010) Characterization of the enzymes encoded by the anthrose biosynthetic operon of Bacillus anthracis
J Bacteriol 192 5053-62. Burgie ES, Holden HM. (2007) Molecular architecture of DesI: a key enzyme in the biosynthesis of desosamine
Biochemistry 46 8999-9006. Chung YS, Kim DH, Seo WM, Lee HC, Liou K, Oh TJ, Sohng JK. (2007) Enzymatic synthesis of dTDP-4-amino-4,6-dideoxy-D-glucose using GerB (dTDP-4-keto-6-deoxy-D-glucose aminotransferase)
Carbohydr Res 342 1412-8. Wang Y, Xu Y, Perepelov AV, Qi Y, Knirel YA, Wang L, Feng L. (2007) Biochemical characterization of dTDP-D-Qui4N and dTDP-D-Qui4NAc biosynthetic pathways in Shigella dysenteriae type 7 and Escherichia coli O7
J Bacteriol 189 8626-35. Articles on 2.6.1.33.b |
last changed |
2019/06/03 09:20 |
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