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B6db families: b
Description dTDP-4-amino-4,6-dideoxy-D-glucose aminotransferase (family b)
Notes A rather heterogeneous family based on the validated enzymes from Escherichia coli O7, Shigella dysenteriae Type 7 and Streptomyces sp.
The family is related to other aminotransferases involved in aminosugar metabolism ( , and to perosamine aminotransferase.
PDB 2PO3;3JU7;
PLP Fold Type I
PLP-dependent Domain
Domain alignment
Domain hmm
Fold type I

Number of sequences 23
Sequences in seed alignment
BacteriaNP_845851 (Bacillus anthracis); AAD44154 (Escherichia coli); ZP_03776774 (Subdoligranulum variabile); NP_484600 (Nostoc sp. PCC 7120); YP_002964696 (Methylobacterium extorquens AM1); NP_954063 (Geobacter sulfurreducens PCA); NP_978343 (Bacillus cereus ATCC 10987); YP_385282 (Geobacter metallireducens); WP_015959521 (Enterobacter sp. 638); ABB52533 (Streptomyces sp. KCTC 0041BP); YP_001391369 (Clostridium botulinum); YP_733457 (Shewanella sp. MR-4); WP_081288437 (Mycobacterium asiaticum); AAR97958 (Shigella dysenteriae); YP_002297065 (Rhodospirillum centenum SW); YP_984877 (Acidovorax sp. JS42); ZP_05639008 (Pseudomonas syringae pv. tabaci); YP_002640303 (Methylophaga sp. DMS010); AAC68684 (Streptomyces venezuelae); ZP_03272660 (Arthrospira maxima CS-328); ZP_01065567 (Vibrio sp. MED222); YP_001488436 (Bacillus pumilus SAFR-032); NP_217919 (Mycobacterium tuberculosis H37Rv);

DISPLAY: Fasta format, alignment, hmm, hmm_local

Reference sequence AAD44154
Domain interval 14-368
Catalytic site 186 K
 Brown HA, Vinogradov E, Gilbert M, Holden HM (2018) The Mycobacterium tuberculosis Complex has a Pathway for the Biosynthesis of 4-Formamido-4,6-Dideoxy-D-Glucose Protein Science 27 1491-1497.

 Dong S, McPherson SA, Wang Y, Li M, Wang P, Turnbough CL Jr, Pritchard DG. (2010) Characterization of the enzymes encoded by the anthrose biosynthetic operon of Bacillus anthracis J Bacteriol 192 5053-62.

 Burgie ES, Holden HM. (2007) Molecular architecture of DesI: a key enzyme in the biosynthesis of desosamine Biochemistry 46 8999-9006.

 Chung YS, Kim DH, Seo WM, Lee HC, Liou K, Oh TJ, Sohng JK. (2007) Enzymatic synthesis of dTDP-4-amino-4,6-dideoxy-D-glucose using GerB (dTDP-4-keto-6-deoxy-D-glucose aminotransferase) Carbohydr Res 342 1412-8.

 Wang Y, Xu Y, Perepelov AV, Qi Y, Knirel YA, Wang L, Feng L. (2007) Biochemical characterization of dTDP-D-Qui4N and dTDP-D-Qui4NAc biosynthetic pathways in Shigella dysenteriae type 7 and Escherichia coli O7 J Bacteriol 189 8626-35.

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last changed 2019/06/03 09:20

B6db families