Activities | Families | Sequences | Fold types | References | Help
B6db families: a
Description UDP-N-acetylbacillosamine transaminase (family a)
Notes A small family of aminotransferases based on the PglE gene product from Campylobacter.
Belongs to a larger subgroup of enzymes (such as GDP-perosamine synthase, involved in the metabolism of NDP-linked amino sugars.
PDB 1O61;4ZTC;
PLP Fold Type I
PLP-dependent Domain
Domain alignment
Domain hmm
Fold type I

Number of sequences 11
Sequences in seed alignment
BacteriaAF108897 (Campylobacter jejuni); BK96993 (Campylobacter coli); EAN08849 (Enterococcus faecium DO); AQR87673 (Bacillus subtilis str. 168); WP_012661960 (Campylobacter lari); WP_038356614 (Bacillus cereus); WP_012140181 (Campylobacter concisus); WP_011979798 (Sulfurovum sp. NBC37-1); WP_005023586 (Helicobacter pullorum); WP_012082619 (Nitratiruptor sp. SB155-2); WP_012500688 (Chloroherpeton thalassium);

DISPLAY: Fasta format, alignment, hmm, hmm_local

Reference sequence AF108897
Domain interval 8-381
Catalytic site 184 K
 Kaundinya CR, Savithri HS, Rao KK, Balaji PV (2018) EpsN from Bacillus subtilis 168 has UDP 2,6-dideoxy 2-acetamido 4-keto glucose aminotransferase activity in vitro Glycobiology 28 802-812.

 Riegert AS, Young NM, Watson DC, Thoden JB, Holden HM (2015) Structure of the external aldimine form of PglE, an aminotransferase required for N,N'-diacetylbacillosamine biosynthesis Protein Sci 24 1609-16.

 Olivier NB, Chen MM, Behr JR, Imperiali B. (2006) In vitro biosynthesis of UDP-N,N'-diacetylbacillosamine by enzymes of the Campylobacter jejuni general protein glycosylation system Biochemistry 45 13659-69.

 Schoenhofen IC, McNally DJ, Vinogradov E, Whitfield D, Young NM, Dick S, Wakarchuk WW, Brisson JR, Logan SM. (2006) Functional characterization of dehydratase/aminotransferase pairs from Helicobacter and Campylobacter: enzymes distinguishing the pseudaminic acid and bacillosamine biosynthetic pathways J Biol Chem. 281 723-32.

Articles on
last changed 2019/12/11 18:07

B6db families