B6db families : 2_6_1_36

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2.6.1.36 a

Activity

2.6.1.36

Description

L-lysine aminotransferase. (family a)

Notes

This family includes L-lysine aminotransferases from gram-positive bacteria. Similar genes also occur in fungi (which indeed are reported to show L-lysine aminotransferase activity) but none of them has been functionally validated.

PDB

2CJH;2CJD;2CIN;

PLP Fold Type

PLP-dependent Domain

Domain alignment
Domain hmm

Fold type I

Number of sequences

Sequences in seed alignment

Bacteria

YP_117193 (Nocardia farcinica IFM 10152); CAM00125 (Saccharopolyspora erythraea); YP_003095555 (Flavobacteriaceae bacterium 3519-10); YP_444935 (Salinibacter ruber); YP_003653276 (Thermobispora bispora); YP_638440 (Mycobacterium sp. MCS); LAT_MYCTU (Mycobacterium tuberculosis); YP_481960 (Frankia sp. CcI3); LAT_STRCL (Streptomyces clavuligerus); YP_066069 (Desulfotalea psychrophila LSv54); LAT_NOCLA (Nocardia lactamdurans); YP_706212 (Rhodococcus sp. RHA1);

DISPLAY: Fasta format, alignment, hmm, hmm_local

Reference sequence

LAT_MYCTU

Domain interval

38-395

Catalytic site

300 K

References

Mani Tripathi S, Ramachandran R. (2006) Overexpression, purification and crystallization of lysine epsilon-aminotransferase (Rv3290c) from Mycobacterium tuberculosis H37Rv Acta Crystallogr Sect F Struct Biol Cryst Commun 62 572-5.

Mani Tripathi S, Ramachandran R. (2006) Direct evidence for a glutamate switch necessary for substrate recognition: crystal structures of lysine epsilon-aminotransferase (Rv3290c) from Mycobacterium tuberculosis H37Rv J Mol Biol 362 877-86.

Coque, J. J.; Liras, P.; Laiz, L.; Martin, J. F. (1991) A gene encoding lysine 6-aminotransferase, which forms the beta-lactam precursor alpha-aminoadipic acid, is located in the cluster of cephamycin biosynthetic genes in Nocardia lactamdurans J Bacteriol 173 6258-64.

Tobin, M.B.; Kovacevic, S.; Madduri, K.; Hoskins, J.A.; Skatrud, P.L.; Vining, L.C.; Stuttard, C.; Miller, J.R. (1991) Localization of the lysine epsilon-aminotransferase (lat) and delta-(L-alpha-aminoadipyl)-L-cysteinyl-D-valine synthetase (pcbAB) genes from Streptomyces clavuligerus and production of lysine epsilon-aminotransferase activity in Escherichia coli J Bacteriol 173 6223-9.

Articles on 2.6.1.36.a

last changed

2011/03/03 11:06