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B6db families:
Description (2-aminoethyl)phosphonate--pyruvate aminotransferase
Notes 2-Aminoethylphosphonate (ciliatine) is the precursor of an array of phosphonated compounds (e.g., phosphonopolysaccharides), which are employed by some organisms for specialized functions such as chemical warfare, cell-cell communication, and host recognition.

Enzymes in this family may be involved both in the synthesis and the degradation of ciliatine; their sequences are distantly related to those in the dhap aminotransferase family and to those of classic alanine-glyoxylate aminotransferases (family

Some biosynthetic enzymes (such as the enzyme from Treponema denticola) are part of bifunctional proteins containing also a N-terminal nucleotidyl transferase domain, which has been removed from the sequences included in the family.

PDB 1M32;
PLP Fold Type I
PLP-dependent Domain
Domain alignment
Domain hmm
Fold type I

Number of sequences 17
Sequences in seed alignment
BacteriaZP_00083884 (Pseudomonas fluorescens); NP_972021 (Treponema denticola ATCC 35405); CAD24488 (Pseudomonas putida); ZP_00028959 (Burkholderia fungorum); AE004560_7 (Pseudomonas aeruginosa PA01); WP_010255470 (Treponema primitia); H82437 (Vibrio cholerae); YP_002773978 (Brevibacillus brevis NBRC 100599); NP_437517 (Sinorhizobium meliloti); WP_045519162 (Bacillus niacini); AAP08310 (Bacillus cereus); CAD63312 (Lactobacillus plantarum WCFS1); NP_655226 (Bacillus anthracis A2012); WP_103599669 (Campylobacter concisus); T46947 (Salmonella typhimurium); ZP_00035195 (Enterococcus faecium);
Other_EukaryaNP_859432 (Leishmania major);

DISPLAY: Fasta format, alignment, hmm, hmm_local

Reference sequence T46947
Domain interval 6-335
Catalytic site 194 K
 Rice K, Batul K, Whiteside J, Kelso J, Papinski M, Schmidt E, Pratasouskaya A, Wang D, Sullivan R, Bartlett C, Weadge JT, Van der Kamp MW, Moreno-Hagelsieb G, Suits MD, Horsman GP (2019) The predominance of nucleotidyl activation in bacterial phosphonate biosynthesis Nat Commun 10 3698.

 Kim, A.D.; Baker, A.S.; Dunaway-Mariano, D.; Metcalf, W.W.; Wanner, B.L.; Martin, B.M. (2002) The 2-aminoethylphosphonate-specific transaminase of the 2-aminoethylphosphonate degradation pathway J Bacteriol 184 4134-40.

Articles on
last changed 2019/08/26 09:15

B6db families