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B6db families: 2.6.1.39.a

2.6.1.39 a
Activity 2.6.1.39
Description 2-aminoadipate aminotransferase (family a)
Notes The S. cerevisiae gene listed here encodes a transaminase with broad substrate specificity; even though it apparently prefers 2-aminoadipate as a substrate, it is annotated as aromatic aminoacid aminotransferase.
The human enzyme listed here is also able to transaminate kynurenine and hydroxykynurenine and is often annotated as kynurenine aminotransferase II.
PDB 2R2N;2VGZ;
PLP Fold Type I
PLP-dependent Domain
Domain alignment
Domain hmm
Fold type I

Reference sequence AAM09683
Domain interval 43-417
Catalytic site 263 K
 
References
 Dindo M, Costanzi E, Pieroni M, Costantini C, Annunziato G, Bruno A, Keller NP, Romani L, Zelante T, Cellini B (2018) Biochemical Characterization of Aspergillus fumigatus AroH, a Putative Aromatic Amino Acid Aminotransferase Front Mol Biosci 5 Art. 104.

 Rząd K, Milewski S, Gabriel I (2018) Versatility of putative aromatic aminotransferases from Candida albicans Fungal Genet Biol 110 26-37.

 Sathyasaikumar KV, Tararina M, Wu HQ, Neale SA, Weisz F, Salt TE, Schwarcz R (2017) Xanthurenic acid formation from 3-hydroxykynurenine in the mammalian Brain: Neurochemical characterization and physiological effects Neuroscience 367 85-97.

 Rząd K, Gabriel I (2015) Characterization of two aminotransferases from Candida albicans Acta Biochim Pol. 62 903-12.

 Karsten WE, Reyes ZL, Bobyk KD, Cook PF, Chooback L. (2011) Mechanism of the aromatic aminotransferase encoded by the Aro8 gene from Saccharomyces cerevisiae Arch Biochem Biophys 516 67-74.

 Han Q, Cai T, Tagle DA, Robinson H, Li J. (2008) Substrate specificity and structure of human aminoadipate aminotransferase/kynurenine aminotransferase II Biosci Rep 28 205-15.

 Goh, D. L.; Patel, A.; Thomas, G. H.; Salomons, G. S.; Schor, D. S.; Jakobs, C.; Geraghty, M. T. (2002) Characterization of the human gene encoding alpha-aminoadipate aminotransferase (AADAT) Mol Genet Metab 76 172-80.

 Urrestarazu, A.; Vissers, S.; Iraqui, I.; Grenson, M. (1998) Phenylalanine- and tyrosine-auxotrophic mutants of Saccharomyces cerevisiae impaired in transamination Mol Gen Genet 257 230-7.

Articles on 2.6.1.39.a
last changed 2018/07/17 16:52

B6db families