Activities | Families | Sequences | Fold types | References | Help
B6db families: a
Description 2-aminoadipate aminotransferase. (family a)
Notes The yeast gene listed here encodes a transaminase with broad substrate specificity; even though it apparently prefers 2-aminoadipate as a substrate, it is annotated as aromatic aminoacid aminotransferase.
The human enzyme listed here may be able to transaminate kynurenine and is sometimes annotated as kynurenine aminotransferase II.
PLP Fold Type I
PLP-dependent Domain
Domain alignment
Domain hmm
Fold type I

Number of sequences
Sequences in seed alignment
FungiEAA58722.1 (Aspergillus nidulans FGSC A4); YGL202W (Saccharomyces cerevisiae ); NP_593270.1 (Schizosaccharomyces pombe); EAA28795.1 (Neurospora crassa); EAA46698.1 (Magnaporthe grisea );
MetazoaNP_035964 (Mus musculus); AAM09683 (Homo sapiens); AAH59968 (Xenopus laevis); CAA90507 (Rattus norvegicus);
Other_EukaryaAAO51520 (Dictyostelium discoideum);

DISPLAY: Fasta format, alignment, hmm, hmm_local

Reference sequence AAM09683
Domain interval 43-417
Catalytic site 263 K
 Karsten WE, Reyes ZL, Bobyk KD, Cook PF, Chooback L. Source (2011) Mechanism of the aromatic aminotransferase encoded by the Aro8 gene from Saccharomyces cerevisiae Arch Biochem Biophys 516 67-74.

 Goh, D. L.; Patel, A.; Thomas, G. H.; Salomons, G. S.; Schor, D. S.; Jakobs, C.; Geraghty, M. T. (2002) Characterization of the human gene encoding alpha-aminoadipate aminotransferase (AADAT) Mol Genet Metab 76 172-80.

 Urrestarazu, A.; Vissers, S.; Iraqui, I.; Grenson, M. (1998) Phenylalanine- and tyrosine-auxotrophic mutants of Saccharomyces cerevisiae impaired in transamination Mol Gen Genet 257 230-7.

Articles on
last changed 2009/06/30 14:04

B6db families