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B6db families:
Description Branched-chain amino acid aminotransferase.
Notes A family of fold-type 4 enzymes, apparently conserved in all kingdoms of life (homologous enzymes from Archaea exist, but they have been omitted from this family as none of them has been functionally characterized).
PLP Fold Type IV
PLP-dependent Domain
Domain alignment
Domain hmm
Fold type IV

Number of sequences
Sequences in seed alignment
BacteriaAAO91868 (Bacillus anthracis); NP_216726 (Mycobacterium tuberculosis H37Rv); CAC12788 (Staphylococcus carnosus); ZP_00061646 (Clostridium thermocellum ); YBGE_BACSU (Bacillus subtilis); NP_607111 (Streptococcus pyogenes ); ILVE_BACSU (Bacillus subtilis); BAC96006 (Vibrio vulnificus); NP_715980 (Shewanella oneidensis); ZP_00071333 (Trichodesmium erythraeum ); AAK79447 (Clostridium acetobutylicum); ZP_00117422 (Cytophaga hutchinsonii); ILVE_HELPY (Helicobacter pylori); AAQ00003 (Prochlorococcus marinus); AAF34406 (Lactococcus lactis ); ILVE_ECOLI (Escherichia coli); AAM72830 (Chlorobium tepidum); ILVE_SALTY (Salmonella typhimurium); AAO91867 (Bacillus cereus);
FungiBCA1_YEAST (Saccharomyces cerevisiae); BCA1_SCHPO (Schizosaccharomyces pombe); BCA2_YEAST (Saccharomyces cerevisiae);
MetazoaAAH59513 (Danio rerio); BCAT_HUMAN (Homo sapiens); BCAT_CAEEL (Caenorhabditis elegans); AAH48072 (Mus musculus); BCAM_RAT (Rattus norvegicus); BCAT_RAT (Rattus norvegicus); AF184916 (Ovis aries); BCAM_HUMAN (Homo sapiens);
ViridiplantaeAAF07191 (Solanum tuberosum); AAO06962 (Oryza sativa); BCA5_ARATH (Arabidopsis thaliana); BCA3_ARATH (Arabidopsis thaliana); AAF07192 (Solanum tuberosum); BCA2_ARATH (Arabidopsis thaliana); BCA6_ARATH (Arabidopsis thaliana); BCA1_ARATH (Arabidopsis thaliana);

DISPLAY: Fasta format, alignment, hmm, hmm_local

Reference sequence ILVE_ECOLI
Domain interval 12-290
Catalytic site 160 K
 Schuster J, Binder S. (2005) The mitochondrial branched-chain aminotransferase (AtBCAT-1) is capable to initiate degradation of leucine, isoleucine and valine in almost all tissues in Arabidopsis thaliana Plant Mol Biol 57 241-54.

 Venos ES, Knodel MH, Radford CL, Berger BJ. (2004) Branched-chain amino acid aminotransferase and methionine formation in Mycobacterium tuberculosis BMC Microbiol 4 39.

 Berger, B.J.; English, S.; Chan, G.; Knodel, M.H. (2003) Methionine regeneration and aminotransferases in Bacillus subtilis, Bacillus cereus, and Bacillus anthracis J Bacteriol 185 2418-31.

 Madsen, S.M.; Beck, H.C.; Ravn, P.; Vrang, A.; Hansen, A.M.; Israelsen, H. (2002) Cloning and inactivation of a branched-chain-amino-acid aminotransferase gene from Staphylococcus carnosus and characterization of the enzyme Appl Environ Microbiol 68 4007-14.

 Yvon, M.; Chambellon, E.; Bolotin, A.; Roudot-Algaron, F. (2000) Characterization and role of the branched-chain aminotransferase (BcaT) isolated from Lactococcus lactis subsp. cremoris NCDO 763 Appl Environ Microbiol 66 571-7.

 Eden, A.; Benvenisty, N. (1998) Characterization of a branched-chain amino-acid aminotransferase from Schizosaccharomyces pombe Yeast 14 189-94.

 Bledsoe, R.K.; Dawson, P.A.; Hutson, S.M. (1997) Cloning of the rat and human mitochondrial branched chain aminotransferases (BCATm) Biochim Biophys Acta 1339 9-13.

 Feild MJ, Nguyen DC, Armstrong FB. (1989 ) Amino acid sequence of Salmonella typhimurium branched-chain amino acid aminotransferase Biochemistry 28 5306-10.

 Inoue, K.; Kuramitsu, S.; Aki, K.; Watanabe, Y.; Takagi, T.; Nishigai, M.; Ikai, A.; Kagamiyama, H. (1988) Branched-chain amino acid aminotransferase of Escherichia coli: overproduction and properties J Biochem (Tokyo) 104 777-84.

Articles on
last changed 2007/11/19 19:06

B6db families