The enzymes from Drosophila and Aedes also show alanine-glyoxylate aminotransferase activity.

We have included in this family a number of bacterial sequences, as they seem very closely related to the metazoan ones. It must be remarked, however, that for none of these bacterial enzymes activity has been tested biochemically. Even for the Nostoc (Anabaena) enzyme, whose structure has been published, functional validation is lacking.