B6db families : 2_6_1

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2.6.1.62

Activity

2.6.1.62

Description

Adenosylmethionine--8-amino-7-oxononanoate aminotransferase.

PDB

1QJ5;1QJ3;1DTY;

PLP Fold Type

PLP-dependent Domain

Domain alignment
Domain hmm

Fold type I

Number of sequences

Sequences in seed alignment

Bacteria

NP_230756 (Vibrio cholerae); NP_876017 (Prochlorococcus marinus); BIOA_ECOLI (Escherichia coli); CAE33824 (Bordetella bronchiseptica); BIOA_ERWHE (Erwinia herbicola); BIOA_HAEIN (Haemophilus influenzae); BIOA_AQUAE (Aquifex aeolicus); NP_846574 (Bacillus anthracis); NP_903880 (Chromobacterium violaceum ); BIOA_BACSH (Bacillus sphaericus); ZP_00044897 (Magnetococcus sp. MC-1); BAB04501 (Bacillus halodurans); AAM71295 (Chlorobium tepidum); ZP_00125119 (Pseudomonas syringae); BIOA_MYCTU (Mycobacterium tuberculosis); AAN49341 (Leptospira interrogans); AAK89425 (Agrobacterium tumefaciens); AAG47794 (Mesorhizobium loti); BAC09487 (Thermosynechococcus elongatus ); NP_625533 (Streptomyces coelicolor ); BAC03240 (Bacillus subtilis); BIOA_SALTY (Salmonella typhimurium); BIOA_CORGL (Corynebacterium glutamicum); BIOA_SERMA (Serratia marcescens); G97067 (Clostridium acetobutylicum);

Fungi

XP_451549 (Kluyveromyces lactis); BIOA_YEAST (Saccharomyces cerevisiae);

DISPLAY: Fasta format, alignment, hmm, hmm_local

Reference sequence

BIOA_ECOLI

Domain interval

28-372

Catalytic site

274 K

References

Bhor, V.M.; Dev, S.; Vasanthakumar, G.R.; Surolia, A. (2006) Spectral and kinetic characterization of 7,8-diaminopelargonic acid synthase from Mycobacterium tuberculosis IUBMB Life 58 225-33.

Mann S, Ploux O. (2006) 7,8-Diaminoperlargonic acid aminotransferase from Mycobacterium tuberculosis, a potential therapeutic target. Characterization and inhibition studies FEBS J 273 4778-89.

Eliot, A. C.; Sandmark, J.; Schneider, G.; Kirsch, J. F. (2002) The dual-specific active site of 7,8-diaminopelargonic acid synthase and the effect of the R391A mutation Biochemistry 41 12582-9.

Kack, H.; Sandmark, J.; Gibson, K.; Schneider, G.; Lindqvist, Y. (1999) Crystal structure of diaminopelargonic acid synthase: evolutionary relationships between pyridoxal-5'-phosphate-dependent enzymes J Mol Biol 291 857-76.

Articles on 2.6.1.62

last changed

2007/09/08 13:19