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B6db families:
Description Valine--pyruvate aminotransferase.
Notes This group of enzymes play a minor role in the bacterial biosynthesis of valine.
The family has been built starting from the only functionally characterized gene (E. coli).

Note that the that enzymes in this family are fold-type I, whereas the enzymes in the family (branched-chain amino acid aminotransferase) are are fold-type IV. This may represent yet another instance of convergent evolution in PLP-dependent enzymes.

PLP Fold Type I
PLP-dependent Domain
Domain alignment
Domain hmm
Fold type I

Number of sequences
Sequences in seed alignment
BacteriaAAN47370 (Leptospira interrogans); AVTA_ECOLI (Escherichia coli); NP_796398 (Vibrio parahaemolyticus); ZP_00074549 (Trichodesmium erythraeum ); NP_407506.1 (Yersinia pestis); CAE12586 (Photorhabdus luminescens); NP_229678.1 (Vibrio cholerae); NP_486851.1 (Nostoc sp. PCC 7120); ZP_00068284 (Microbulbifer degradans 2-40); NP_283446 (Neisseria meningitidis Z2491); ZP_00107715 (Nostoc punctiforme); AAL22524.1 (Salmonella typhimurium); NP_682532 (Thermosynechococcus elongatus BP-1);

DISPLAY: Fasta format, alignment, hmm, hmm_local

Reference sequence AVTA_ECOLI
Domain interval 30-405
Catalytic site 249 K
 Wang, M. D.; Liu, L.; Wang, B. M.; Berg, C. M. (1987) Cloning and characterization of the Escherichia coli K-12 alanine- valine transaminase (avtA) gene J Bacteriol 169 4228-34.

Articles on
last changed 2007/12/07 18:29

B6db families