B6db families : 2_6_1

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2.6.1.66

Activity

2.6.1.66

Description

Valine--pyruvate aminotransferase.

Notes

This group of enzymes play a minor role in the bacterial biosynthesis of valine.
The family has been built starting from the only functionally characterized gene (E. coli).

Note that the that enzymes in this family are fold-type I, whereas the enzymes in the 2.6.1.42 family (branched-chain amino acid aminotransferase) are are fold-type IV. This may represent yet another instance of convergent evolution in PLP-dependent enzymes.

PLP Fold Type

PLP-dependent Domain

Domain alignment
Domain hmm

Fold type I

Number of sequences

Sequences in seed alignment

Bacteria

CAE12586 (Photorhabdus luminescens); AAL22524.1 (Salmonella typhimurium); ZP_00074549 (Trichodesmium erythraeum ); ZP_00107715 (Nostoc punctiforme); NP_486851.1 (Nostoc sp. PCC 7120); ZP_00068284 (Microbulbifer degradans 2-40); NP_283446 (Neisseria meningitidis Z2491); NP_407506.1 (Yersinia pestis); AVTA_ECOLI (Escherichia coli); NP_796398 (Vibrio parahaemolyticus); NP_682532 (Thermosynechococcus elongatus BP-1); AAN47370 (Leptospira interrogans); NP_229678.1 (Vibrio cholerae);

DISPLAY: Fasta format, alignment, hmm, hmm_local

Reference sequence

AVTA_ECOLI

Domain interval

30-405

Catalytic site

249 K

References

Wang, M. D.; Liu, L.; Wang, B. M.; Berg, C. M. (1987) Cloning and characterization of the Escherichia coli K-12 alanine- valine transaminase (avtA) gene J Bacteriol 169 4228-34..

Articles on 2.6.1.66

last changed

2007/12/07 18:29