B6db families : 2_6_1

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2.6.1.89

Activity

2.6.1.89

Description

dTDP-3-dehydro-6-deoxy-D-glucose aminotransferase

Notes

Only one functionally validated gene product (from T. thermosaccharolyticum).

These bacterial enzymes are phylogenetically related to (and very difficult to distinguish from ) a number of other NDP-hexose aminotransferases, in particular those in family 2.6.1.106.

PDB

3FRK;

PLP Fold Type

PLP-dependent Domain

Domain alignment
Domain hmm

Fold type I

Number of sequences

Sequences in seed alignment

Bacteria

YP_001717829 (Candidatus Desulforudis audaxviator); YP_001309709 (Clostridium beijerinckii NCIMB 8052); ZP_03486200 (Roseburia intestinalis); AAR85519 (Thermoanaerobacterium thermosaccharolyticum); AAA21342 (Streptomyces fradiae);

DISPLAY: Fasta format, alignment, hmm, hmm_local

Reference sequence

AAR85519

Domain interval

13-362

Catalytic site

186 K

References

Thoden JB, Schäffer C, Messner P, Holden HM. (2009) Structural Analysis of QdtB, an Aminotransferase Required for the Biosynthesis of dTDP-3-acetamido-3,6-dideoxy-alpha-d-glucose Biochemistry 48 1553–1561.

Westman EL, McNally DJ, Charchoglyan A, Brewer D, Field RA, Lam JS. (2009) Characterization of WbpB, WbpE, and WbpD and reconstitution of a pathway for the biosynthesis of UDP-2,3-diacetamido-2,3-dideoxy-D-mannuronic acid in Pseudomonas aeruginosa J Biol Chem 284 11854-62.

Pföstl A, Zayni S, Hofinger A, Kosma P, Schäffer C, Messner P. (2008) Biosynthesis of dTDP-3-acetamido-3,6-dideoxy-alpha-D-glucose Biochem J 410 187-94.

Melançon CE 3rd, Hong L, White JA, Liu YN, Liu HW. (2007) Characterization of TDP-4-keto-6-deoxy-D-glucose-3,4-ketoisomerase from the D-mycaminose biosynthetic pathway of Streptomyces fradiae: in vitro activity and substrate specificity studies Biochemistry 46 577-90.

Articles on 2.6.1.89

last changed

2017/09/08 09:21