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B6db families: 2.9.1.2

2.9.1.2
Activity 2.9.1.2
Description O-phospho-L-seryl-tRNA(Sec):L-selenocysteinyl-tRNA synthase
Notes Rather compact family, composed of eukaryotic and archaeal (methanogens) enzymes.
PDB 3BC8;3BCB;2Z67;
PLP Fold Type I
PLP-dependent Domain
Domain alignment
Domain hmm
Fold type I

Number of sequences
20
Sequences in seed alignment
ArchaeaSPCS_METMP (Methanococcus maripaludis); WP_007043495 (Methanotorris formicicus); SPCS_METKA (Methanopyrus kandleri); SPCS_METJA (Methanocaldococcus jannaschii); WP_048203528 (Methanocaldococcus infernus);
MetazoaBAC28410 (Mus musculus); NP_058651 (Homo sapiens); SPCS_CAEEL (Caenorhabditis elegans); EAT44258 (Aedes aegypti); NP_001093359 (Xenopus laevis); XP_001362538 (Monodelphis domestica); XP_781218 (Strongylocentrotus purpuratus); NP_956448 (Danio rerio); XP_625123 (Apis mellifera);
Other_EukaryaXP_641299 (Dictyostelium discoideum AX4); EAN80252 (Trypanosoma brucei); XP_003858779 (Leishmania donovani); XP_001032036 (Tetrahymena thermophila); XP_001455539 (Paramecium tetraurelia); XP_001350460 (Plasmodium falciparum);

DISPLAY: Fasta format, alignment, hmm, hmm_local


Reference sequence BAC28410
Domain interval 61-459
Catalytic site 284 K
 
References
 Manhas R, Gowri VS, Madhubala R (2016) Leishmania donovani Encodes a Functional Selenocysteinyl-tRNA Synthase J Biol Chem 291 1203-20.

 Palioura S, Sherrer RL, Steitz TA, Söll D, Simonovic M. (2009) The human SepSecS-tRNASec complex reveals the mechanism of selenocysteine formation Science 325 321-5.

 Araiso Y, Palioura S, Ishitani R, Sherrer RL, O'Donoghue P, Yuan J, Oshikane H, Domae N, Defranco J, Söll D, Nureki O (2008) Structural insights into RNA-dependent eukaryal and archaeal selenocysteine formation Nucleic Acids Res 36 1187-99.

 Ganichkin OM, Xu XM, Carlson BA, Mix H, Hatfield DL, Gladyshev VN, Wahl MC. (2008) Structure and catalytic mechanism of eukaryotic selenocysteine synthase J Biol Chem 283 5849-65.

 Xu, X.M.; Carlson, B.A.; Mix, H.; Zhang, Y.; Saira K.; Glass, R.S.; Berry, M.J.; Gladyshev, V.N.; Hatfield, D.L. (2007) Biosynthesis of selenocysteine on its tRNA in eukaryotes PLoS Biol. 5 e4.

 Yuan J, Palioura S, Salazar JC, Su D, O'Donoghue P, Hohn MJ, Cardoso AM, Whitman WB, Söll D. (2006) RNA-dependent conversion of phosphoserine forms selenocysteine in eukaryotes and archaea Proc Natl Acad Sci U S A 103 18923-7.

Articles on 2.9.1.2
last changed 2017/08/08 12:03

B6db families