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B6db families: 3.7.1.3

3.7.1.3
Activity 3.7.1.3
Description Kynureninase
Notes The family encompasses bacterial, fungal and animal genes (the activity has not been described in other organisms).
Note that many fungi contain two kinureninase genes - presumably, one encodes an inducible enzyme, whereas expression of the other is constitutive.
PDB 1QZ9;2HZP;
PLP Fold Type I
PLP-dependent Domain
Domain alignment
Domain hmm
Fold type I

Reference sequence KYNU_RAT
Domain interval 69-450
Catalytic site 276 K
 
References
 Zummo FP, Marineo S, Pace A, Civiletti F, Giardina A, Puglia AM (2012) Tryptophan catabolism via kynurenine production in Streptomyces coelicolor: identification of three genes coding for the enzymes of tryptophan to anthranilate pathway Appl Microbiol Biotechnol 94 719-28.

 Walsh, H. A.; Botting, N. P. (2002) Purification and biochemical characterization of some of the properties of recombinant human kynureninase Eur J Biochem 269 2069-74.

 Koushik, S. V.; Sundararaju, B.; McGraw, R. A.; Phillips, R. S. (1997) Cloning, sequence, and expression of kynureninase from Pseudomonas fluorescens Arch Biochem Biophys 344 301-8.

 Toma, S.; Nakamura, M.; Tone, S.; Okuno, E.; Kido, R.; Breton, J.; Avanzi, N.; Cozzi, L.; Speciale, C.; Mostardini, M.; Gatti, S.; Benatti, L. (1997) Cloning and recombinant expression of rat and human kynureninase FEBS Lett 408 5-10.

Articles on 3.7.1.3
last changed 2007/12/20 20:55

B6db families