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B6db families: 3.7.1.3

3.7.1.3
Activity 3.7.1.3
Description Kynureninase
Notes The family encompasses bacterial, fungal and animal genes (the activity has not been described in other organisms).
Note that many fungi contain two kinureninase genes - presumably, one encodes an inducible enzyme, whereas expression of the other is constitutive.
PDB 1QZ9;2HZP;
PLP Fold Type I
PLP-dependent Domain
Domain alignment
Domain hmm
Fold type I

Number of sequences
27
Sequences in seed alignment
BacteriaNP_627839 (Streptomyces coelicolor); ZP_00029890 (Burkholderia fungorum); NP_518880 (Ralstonia solanacearum); NP_641933 (Xanthomonas axonopodis pv. citri str. 306); NP_636924 (Xanthomonas campestris pv. campestris str. ATCC 33913); NP_102390 (Mesorhizobium loti); ZP_00118864 (Cytophaga hutchinsonii); NP_279867 (Halobacterium sp. NRC-1); AAQ86995 (Polaribacter filamentus); BAC12712 (Oceanobacillus iheyensis); AAP05310 (Chlamydophila caviae ); NP_656639 (Bacillus anthracis A2012); 1QZ9A (Pseudomonas fluorescens); WP_003114854 (Pseudomonas aeruginosa PAO1); CAE30744 (Bordetella bronchiseptica);
FungiKYNU_YEAST (Saccharomyces cerevisiae); EAA57815 (Aspergillus nidulans); EAA72333 (Gibberella zeae); EAA27546 (Neurospora crassa);
MetazoaNP_001136399 (Bombyx mori); XP_002114057 (Trichoplax adhaerens); KYNU_HUMAN (Homo sapiens); CAE68870 (Caenorhabditis briggsae); XP_013142498 (Papilio polytes); KYNU_RAT (Rattus norvegicus); KYNU_CAEEL (Caenorhabditis elegans); XP_130193 (Mus musculus);

DISPLAY: Fasta format, alignment, hmm, hmm_local


Reference sequence KYNU_RAT
Domain interval 69-450
Catalytic site 276 K
 
References
 Zummo FP, Marineo S, Pace A, Civiletti F, Giardina A, Puglia AM (2012) Tryptophan catabolism via kynurenine production in Streptomyces coelicolor: identification of three genes coding for the enzymes of tryptophan to anthranilate pathway Appl Microbiol Biotechnol 94 719-28.

 Walsh, H. A.; Botting, N. P. (2002) Purification and biochemical characterization of some of the properties of recombinant human kynureninase Eur J Biochem 269 2069-74.

 Koushik, S. V.; Sundararaju, B.; McGraw, R. A.; Phillips, R. S. (1997) Cloning, sequence, and expression of kynureninase from Pseudomonas fluorescens Arch Biochem Biophys 344 301-8.

 Toma, S.; Nakamura, M.; Tone, S.; Okuno, E.; Kido, R.; Breton, J.; Avanzi, N.; Cozzi, L.; Speciale, C.; Mostardini, M.; Gatti, S.; Benatti, L. (1997) Cloning and recombinant expression of rat and human kynureninase FEBS Lett 408 5-10.

Articles on 3.7.1.3
last changed 2007/12/20 20:55

B6db families