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B6db families:
Description 2-[(L-alanin-3-ylcarbamoyl)methyl]-2-hydroxybutanedioate decarboxylase
Notes Peculiar family of fold-type III enzymes, involved in siderophore biosynthesis.
Distantly related to the specialized decarboxylases FlvO and VinO.
PLP Fold Type III
PLP-dependent Domain
Domain alignment
Domain hmm
Fold type III

Number of sequences 11
Sequences in seed alignment
BacteriaWP_010988718 (Streptomyces avermitilis); WP_104422370 (Methylobacter tundripaludum); WP_011515897 (Cupriavidus metallidurans); WP_011634783 (Nitrosomonas eutropha); WP_011311229 (Thiobacillus denitrificans); WP_131522814 (Staphylococcus aureus); WP_047436287 (Staphylococcus argenteus); WP_012894742 (Streptosporangium roseum); WP_011485646 (Polaromonas sp. JS666); WP_012245098 (Renibacterium salmoninarum ATCC 33209); WP_011003736 (Ralstonia solanacearum GMI1000);

DISPLAY: Fasta format, alignment, hmm, hmm_local

Reference sequence WP_131522814
Domain interval 20-371
Catalytic site 50 K
 Tang J, Ju Y, Gu Q, Xu J, Zhou H (2019) Structural insights into substrate recognition and activity regulation of the key decarboxylase SbnH in staphyloferrin B biosynthesis J Mol Biol 431 4868-4881.

 Cheung J, Beasley FC, Liu S, Lajoie GA, Heinrichs DE (2009) Molecular characterization of staphyloferrin B biosynthesis in Staphylococcus aureus Mol Microbiol 74 1594-608.

Articles on
last changed 2019/10/23 12:50

B6db families