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B6db families: a
Description Glutamate decarboxylase (family a)
Notes This family encompasses exclusively metazoan glutamate decarboxylase sequences.
Two isoforms of glutamate decarboxylase, encoded by different genes, occur in mammalian tissues: a 67-kDa form (DCE1 or GAD67) and a 65-kDa form (DCE2 or GAD65).
Alternate splicing produces smaller variants of GAD67 in the brain of mice and rat embryos. Another splice variant of GAD67 (termed GAD25 and devoid of GAD enzymatic activity) is produced in human islets, testis and adrenal cortex.
PLP Fold Type I
PLP-dependent Domain
Domain alignment
Domain hmm
Fold type I

Number of sequences 22
Sequences in seed alignment
MetazoaXP_019920275 (Crassostrea gigas); AFX68721 (Mus musculus); AAF73186 (Carassius auratus); AAA96273 (Xenopus laevis); NP_919400 (Danio rerio); AFX68715 (Ctenocephalides felis); DCE1_HUMAN (Homo sapiens); NP_499689 (Caenorhabditis elegans); DCE1_FELCA (Felis silvestris catus); DCE2_PIG (Sus scrofa); XP_013417802 (Lingula anatina); DCE2_HUMAN (Homo sapiens); EAA11955 (Anopheles gambiae str. PEST); DCE1_PIG (Sus scrofa); DCE1_MOUSE (Mus musculus); P20228 (Drosophila melanogaster); DCE2_MOUSE (Mus musculus); DCE1_RAT (Rattus norvegicus); AAF73187 (Carassius auratus); BAB88854 (Ciona intestinalis); DCE2_RAT (Rattus norvegicus); CAE69543 (Caenorhabditis briggsae);

DISPLAY: Fasta format, alignment, hmm, hmm_local

Reference sequence DCE1_RAT
Domain interval 143-517
Catalytic site 404 K
 Li M, Wang L, Qiu L, Wang W, Xin L, Xu J, Wang H, Song L (2016) A glutamic acid decarboxylase (CgGAD) highly expressed in hemocytes of Pacific oyster Crassostrea gigas Dev Comp Immunol 63 56-65.

 Ilg T, Berger M, Noack S, Rohwer A, Gaßel M. (2013) Glutamate decarboxylase of the parasitic arthropods Ctenocephalides felis and Rhipicephalus microplus: gene identification, cloning, expression, assay development, identification of inhibitors by high throughput screening and comparison with the orthologs from Drosophila melanogaster and mouse. Insect Biochem Mol Biol. 43 162-77.

 Jin, Y.; Jorgensen, E.; Hartwieg, E.; Horvitz, H.R. (1999) The Caenorhabditis elegans gene unc-25 encodes glutamic acid decarboxylase and is required for synaptic transmission but not synaptic development J Neurosci 19 539-48.

 Bu, D. F.; Erlander, M. G.; Hitz, B. C.; Tillakaratne, N. J.; Kaufman, D. L.; Wagner-McPherson, C. B.; Evans, G. A.; Tobin, A. J. (1992) Two human glutamate decarboxylases, 65-kDa GAD and 67-kDa GAD, are each encoded by a single gene Proc Natl Acad Sci U S A 89 2115-9.

 Jackson, F.R.; Newby, L.M.; Kulkarni, S.J. (1990) Drosophila GABAergic systems: sequence and expression of glutamic acid decarboxylase J Neurochem 54 1068-78.

 Wyborski, R. J.; Bond, R. W.; Gottlieb, D. I. (1990) Characterization of a cDNA coding for rat glutamic acid decarboxylase Brain Res Mol Brain Res 8 193-8.

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last changed 2008/01/03 12:33

B6db families