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B6db families: b
Description Lysine decarboxylase. (family b)
Notes A compact family of proteins mostly from enterobacteria.
The sequences are related to those in family 4.1.17_2 (bacterial ornithine decarboxylases) and 4.1.19_2 (Arginine decarboxylases).
In addition to the PLP-dependent domain, they encompass two additional, smaller domains (one at the N-terminus, the other at the N-terminus).
PDB 3Q16;
PLP Fold Type I
PLP-dependent Domain
Domain alignment
Domain hmm
Fold type I

Number of sequences
Sequences in seed alignment
BacteriaDCLY_HAFAL (Hafnia alvei); DCLY_SALTY (Salmonella typhimurium); DCLZ_ECOLI (Escherichia coli); DCLY_ECOLI (Escherichia coli); BAB16718 (Moritella japonica); ZP_01783605 (Haemophilus influenzae 22.1-21); AAD18126 (Eikenella corrodens); NP_760922 (Vibrio vulnificus);

DISPLAY: Fasta format, alignment, hmm, hmm_local

Reference sequence DCLZ_ECOLI
Domain interval 130-562
Catalytic site 367 K
 Kanjee U1, Gutsche I, Alexopoulos E, Zhao B, El Bakkouri M, Thibault G, Liu K, Ramachandran S, Snider J, Pai EF, Houry WA. (2011) Linkage between the bacterial acid stress and stringent responses: the structure of the inducible lysine decarboxylase. EMBO J. 30 931-44.

 Levine, M.; Progulske-Fox, A.; Denslow, N.D.; Farmerie, W.G.; Smith, D.M.; Swearingen, W.T.; Miller, F.C.; Liang, Z.; Roe, B.A.; Pan, H.Q. (2001) Identification of lysine decarboxylase as a mammalian cell growth inhibitor in Eikenella corrodens: possible role in periodontal disease Microb Pathog 30 179-92.

 Lemonnier, M.; Lane, D. (1998) Expression of the second lysine decarboxylase gene of Escherichia coli Microbiology 144 751-60.

 Fecker, L.F.; Beier, H.; Berlin, J. (1986) Cloning and characterization of a lysine decarboxylase gene from Hafnia alvei Mol Gen Genet 203 177-184.

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last changed 2014/07/11 11:43

B6db families