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4.1.1.19 1 |
Activity |
4.1.1.19 |
Description |
Arginine decarboxylase (family 1) |
Notes |
This family includes plant and proteobacterial (biosynthetic) arginine decarboxylases, which are fold-type III enzymes.
In contrast, the Escherichia coli biodegradative arginine decarboxylase and other bacterial arginine decarboxylases are fold-type I enzymes and have been grouped in family 4.1.1.19_2. |
PDB |
3NZP;3NZQ; |
PLP Fold Type |
III |
PLP-dependent Domain |
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Number of sequences |
29 |
Sequences in seed alignment |
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Reference sequence |
SPE1_ARATH |
Domain interval |
107-384 |
Catalytic site |
136 K |
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References |
Alam M, Srivastava A, Dutta A, Sau AK (2018) Biochemical and biophysical studies of Helicobacter pylori arginine decarboxylase, an enzyme important for acid adaptation in host IUBMB Life 70 658-669. Docimo T, Reichelt M, Schneider B, Kai M, Kunert G, Gershenzon J, D'Auria JC. (2012) The first step in the biosynthesis of cocaine in Erythroxylum coca: the characterization of arginine and ornithine decarboxylases. Plant Mol Biol. 78 599-615. Forouhar F1, Lew S, Seetharaman J, Xiao R, Acton TB, Montelione GT, Tong L. (2010) Structures of bacterial biosynthetic arginine decarboxylases. Acta Crystallogr Sect F Struct Biol Cryst Commun. 66 1562-6. Hanfrey, C.; Sommer, S.; Mayer, M.J., Burtin, D., Michael, A.J. (2001) Arabidopsis polyamine biosynthesis: absence of ornithine decarboxylase and the mechanism of arginine decarboxylase activity Plant J 27 551-60. Sekowska, A.; Bertin, P.; Danchin, A. (1998) Characterization of polyamine synthesis pathway in Bacillus subtilis 168 Mol Microbiol 29 851-8. Bell, E.; Malmberg, R.L. (1990) Analysis of a cDNA encoding arginine decarboxylase from oat reveals similarity to the Escherichia coli arginine decarboxylase and evidence of protein processing Mol Gen Genet 224 431-6. Moore, R. C.; Boyle, S. M. (1990) Nucleotide sequence and analysis of the speA gene encoding biosynthetic arginine decarboxylase in Escherichia coli J Bacteriol 172 4631-40. Articles on 4.1.1.19.1 |
last changed |
2018/05/23 15:11 |
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