B6db families : 4_1_1_22

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4.1.1.22 a

Activity

4.1.1.22

Description

Histidine decarboxylase (family a)

Notes

This family encompasses a group of closely related enzymes from gram-negative bacteria. The closest validated homologs are plant serine decarboxylases.
His decarboxylases from gram-positive bacteria use a pyruvoyl cofactor instead of of PLP.

PLP Fold Type

PLP-dependent Domain

Domain alignment
Domain hmm

Fold type I

Number of sequences

Sequences in seed alignment

Bacteria

YP_001144043 (Aeromonas salmonicida); AAO65983 (Photobacterium phosphoreum); DCHS_KLEPL (Klebsiella planticola); YP_001340499 (Marinomonas sp. MWYL1); AAO92385 (Listonella anguillarum); BAC87908 (Acinetobacter baumannii); CAA70530 (Pseudomonas fluorescens); DCHS_ENTAE (Enterobacter aerogenes); YP_608112 (Pseudomonas entomophila); DCHS_MORMO (Morganella morganii);

DISPLAY: Fasta format, alignment, hmm, hmm_local

Reference sequence

DCHS_MORMO

Domain interval

22-331

Catalytic site

233 K

References

Sattely ES, Walsh CT (2008) A latent oxazoline electrophile for N-O-C bond formation in pseudomonine biosynthesis J Am Chem Soc 130 12282-4.

Morii H, Kasama K, Herrera-Espinoza R. (2006) Cloning and sequencing of the histidine decarboxylase gene from Photobacterium phosphoreum and its functional expression in Escherichia coli J Food Prot 69 1768-76.

Tolmasky, M.E.; Actis, L.A.; Crosa, J.H. (1995) A histidine decarboxylase gene encoded by the Vibrio anguillarum plasmid pJM1 is essential for virulence: histamine is a precursor in the biosynthesis of anguibactin Mol Microbio 15 87-95.

Kamath, A.V.; Vaaler, G.L.; Snell, E.E. (1991) Pyridoxal phosphate-dependent histidine decarboxylases. Cloning, sequencing, and expression of genes from Klebsiella planticola and Enterobacter aerogenes and properties of the overexpressed enzymes J Biol Chem 266 9432-7.

Vaaler, G. L.; Brasch, M. A.; Snell, E. E. (1986) Pyridoxal 5'-phosphate-dependent histidine decarboxylase. Nucleotide sequence of the hdc gene and the corresponding amino acid sequence J Biol Chem 261 11010-4.

Articles on 4.1.1.22.a

last changed

2008/01/24 18:18