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|
4.1.1.22 b |
Activity |
4.1.1.22 |
Description |
Histidine decarboxylase (family b) |
Notes |
Family entirely composed of metazoan enzymes, very closely related to DOPA decarboxylases (EC 4.1.1.28).
These sequences are generally over 600 aa long; however, in mammalian cells, mature histidine decarboxylase is approximately 512 aa long, due to a C-terminal truncation. |
PLP Fold Type |
I |
PLP-dependent Domain |
|
Number of sequences |
11 |
Sequences in seed alignment |
|
Reference sequence |
DCHS_HUMAN |
Domain interval |
36-414 |
Catalytic site |
305 K |
| |
References |
Moya-Garcia AA, Medina MA, Sánchez-Jiménez F.
(2005) Mammalian histidine decarboxylase: from structure to function Bioessays 27 57-63. Rodriguez-Caso, C.; Rodriguez-Agudo, D.; Moya-Garcia, A.A., Fajardo, I.; Medina, M.A.; Subramaniam, V.; Sanchez-Jimenez, F.
(2003) Local changes in the catalytic site of mammalian histidine decarboxylase can affect its global conformation and stability Eur J Biochem 270 4376-87. Yatsunami, K.; Tsuchikawa, M.; Kamada, M.; Hori, K.; Higuchi, T.
(1995) Comparative studies of human recombinant 74- and 54-kDa L-histidine decarboxylases J Biol Chem 270 30813-7. Martin, S. A.; Bulfield, G. (1984) A structural gene (Hdc-s) for mouse kidney histidine decarboxylase Biochem Genet 22 645-56. Articles on 4.1.1.22.b |
last changed |
2008/01/24 18:16 |
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