|
|
| |
4.1.1.25 a |
| Activity |
4.1.1.25 |
| Description |
Tyrosine decarboxylase (family a) |
| Notes |
This family has been constructed around three validated bacterial sequences, but it also includes a closely homologous archaeal sequence.
Fungal Phe decarboxylases (Family 4.1.1.53) are very similar in sequence (apart from an additional C-terminus domain) and retain a substantial activity towards tyrosine.
Plant enzymes with tyrosine decarboxylase activity have been included into EC 4.1.1.28 (Aromatic amino acid decarboxylase). |
| PDB |
5HSI; |
| PLP Fold Type |
I |
| PLP-dependent Domain |
|
| Number of sequences |
10 |
| Sequences in seed alignment |
|
| Reference sequence |
AAM46082 |
| Domain interval |
57-513 |
| Catalytic site |
392 K |
| | |
|---|
| References |
Zhu H, Xu G, Zhang K, Kong X, Han R, Zhou J, Ni Y (2016) Crystal structure of tyrosine decarboxylase and identification of key residues involved in conformational swing and substrate binding Sci Rep 6 27779. Marcobal A, de las Rivas B, Muñoz R. (2006) First genetic characterization of a bacterial beta-phenylethylamine biosynthetic enzyme in Enterococcus faecium RM58 FEMS Microbiol Lett 258 144-9. Fernández M, Linares DM, Alvarez MA. (2004) Sequencing of the tyrosine decarboxylase cluster of Lactococcus lactis IPLA 655 and the development of a PCR method for detecting tyrosine decarboxylating lactic acid bacteria J Food Prot 67 2521-9. Connil, N.; Le Breton, Y.; Dousset, X.; Auffray, Y.; Rince, A.; Prevost, H. (2002) Identification of the Enterococcus faecalis tyrosine decarboxylase operon involved in tyramine production Appl Environ Microbiol 68 3537-44. Lucas, P.; Lonvaud-Funel, A. (2002) Purification and partial gene sequence of the tyrosine decarboxylase of Lactobacillus brevis IOEB 9809 FEMS Microbiol Lett 211 85-9. |
| last changed |
2018/12/19 09:48 |
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