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B6db families: 4.1.1.28

4.1.1.28
Activity 4.1.1.28
Description Aromatic-L-amino-acid decarboxylase
Notes Phylogenetically, this family is rather compact, but strictly related to eukaryotic histidine decarboxylase.

Functionally, these enzymes are rather diverse (even though the generic name of the activity can justify their inclusion in a single family). In fact, these enzymes can act on L-Phenylalanine, L-Tyrosine, 3,4-Dihydroxy-L-phenylalanine, 5-Hydroxy-L-tryptophan, 5-Hydroxykynurenamine.

Although plant and animal enzymes share extensive amino acid similarity, they display striking differences in their substrate specificities. AADCs from metazoa accept a broad range of aromatic L-amino acids, whereas plant enzymes appear specialized for L-amino acids with either indole or phenol side chains, but not both.

The plant sequences are tightly related to, and barely distinguishable from, phenylacetaldehyde synthases (4.1.1.109 subafamilies a and b). These are specialized enzymes that stoichiometrically couple the decarboxylation of Phe with the further conversion of phenylethylamine to phenylacetaldehyde.

PDB 1JS6;
PLP Fold Type I
PLP-dependent Domain
Domain alignment
Domain hmm
Fold type I

Number of sequences 0
Reference sequence DDC_BOVIN
Domain interval 35-414
Catalytic site 303 K
 
References Articles on 4.1.1.28
last changed 2019/06/19 11:35

B6db families