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4.1.2.27 |
Activity |
4.1.2.27 |
Description |
Sphinganine-1-phosphate aldolase |
Notes |
Compact family of eukaryotic and bacterial enzymes with regulatory functions.
Similar sequences occur in some archaea, but the activity of the gene products is not documented. |
PDB |
3MAD;3MAF;3MBB;3MAF;5K1R; |
PLP Fold Type |
I |
PLP-dependent Domain |
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Number of sequences |
35 |
Sequences in seed alignment |
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Reference sequence |
NP_003892 |
Domain interval |
150-456 |
Catalytic site |
353 K |
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References |
McLean CJ, Marles-Wright J, Custodio R, Lowther J, Kennedy AJ, Pollock J, Clarke DJ, Brown AR, Campopiano DJ (2017) Characterization of homologous sphingosine-1-phosphate lyase isoforms in the bacterial pathogen Burkholderia pseudomallei J Lipid Res 58 137-150. Huwiler A, Bourquin F, Kotelevets N, Pastukhov O, Capitani G, Grütter MG, Zangemeister-Wittke U (2011) A prokaryotic S1P lyase degrades extracellular S1P in vitro and in vivo: implication for treating hyperproliferative disorders PLoS One 6 e22436. Li, G.; Foote, C.; Alexander, S.; Alexander, H. (2001) Sphingosine-1-phosphate lyase has a central role in the development of Dictyostelium discoideum Development 128 3473-83. Van Veldhoven, P.P.; Gijsbers, S.; Mannaerts, G.P.; Vermeesch, J.R.; Brys, V. (2000) Human sphingosine-1-phosphate lyase: cDNA cloning, functional expression studies and mapping to chromosome 10q22(1) Biochim Biophys Acta 1487 128-34. Zhou, J.; Saba, J. D. (1998) Identification of the first mammalian sphingosine phosphate lyase gene and its functional expression in yeast Biochem Biophys Res Commun 242 502-7. Saba, J.D.; Nara F.; Bielawska, A.; Garrett, S.; Hannun, Y.A. (1997) The BST1 gene of Saccharomyces cerevisiae is the sphingosine-1-phosphate lyase. J Biol Chem 272 26087-90. Articles on 4.1.2.27 |
last changed |
2017/11/02 09:49 |
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