B6db families : 4_2_1

	Activities \| Families \| Sequences \| Fold types \| References \| Help

4.2.1.164

Activity

4.2.1.164

Description

dTDP-4-dehydro-2,6-dideoxy-D-glucose 3-dehydratase

Notes

A small family, related to family 1.17.1.1.

Genes for these enzymes regularly cluster with genes encoding dTDP-4-dehydro-2,3,6-trideoxy-D-glucose 4-aminotransferase (Family 2.6.1.110), which catalyzes the next step in the pathway.

PLP Fold Type

PLP-dependent Domain

Domain alignment
Domain hmm

Fold type I

Number of sequences

Sequences in seed alignment

Bacteria

AAY88934 (Saccharopolyspora pogona); KPL32269 (Streptomyces anulatus); ACK77744 (Kitasatospora aureofaciens); WP_077004301 (Saccharothrix sp. ALI-22-I); CAM96591 (Streptomyces ambofaciens); AAG23278 (Saccharopolyspora spinosa);

DISPLAY: Fasta format, alignment, hmm, hmm_local

Reference sequence

AAG23278

Domain interval

66-455

Catalytic site

n/a

References

Hong L, Zhao Z, Melançon CE 3rd, Zhang H, Liu HW (2008) In vitro characterization of the enzymes involved in TDP-D-forosamine biosynthesis in the spinosyn pathway of Saccharopolyspora spinosa J Am Chem Soc 130 4954-67.

Hong L, Zhao Z, Liu HW (2006) Characterization of SpnQ from the spinosyn biosynthetic pathway of Saccharopolyspora spinosa: mechanistic and evolutionary implications for C-3 deoxygenation in deoxysugar biosynthesis J Am Chem Soc 128 14262-3.

Articles on 4.2.1.164

last changed

2017/09/07 12:18