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4.2.1.22 |
Activity |
4.2.1.22 |
Description |
Cystathionine beta-synthase |
Notes |
Mammalian cystathionine beta-synthases, but not the yeast enzyme, also bind a heme molecule.
Additional_domain CBS_HUMAN 1-400 |
PDB |
1JBQ;1M54;4L0D;5OHX; |
PLP Fold Type |
II |
PLP-dependent Domain |
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Number of sequences |
24 |
Sequences in seed alignment |
|
Reference sequence |
CBS_HUMAN |
Domain interval |
80-376 |
Catalytic site |
119 K |
| |
References |
Chang Z, Vining LC (2002) Biosynthesis of sulfur-containing amino acids in Streptomyces venezuelae ISP5230: roles for cystathionine beta-synthase and transsulfuration Microbiology 148 2135-2147. Li, D. Y.; Ji, X. S.; Yu, J.; Chen, M. J.; Yuan, Z. Y. (2001) PCR Based Cloning and Sequence Analysis of the Pichia pastoris Cystathionine beta-Synthase Gene Sheng Wu Hua Xue Yu Sheng Wu Wu Li Xue Bao 33 600-606. Nozaki, T.; Shigeta, Y.; Saito-Nakano, Y.; Imada, M.; Kruger, W.D. (2001) Characterization of transsulfuration and cysteine biosynthetic pathways in the protozoan hemoflagellate, Trypanosoma cruzi. Isolation and molecular characterization of cystathionine beta-synthase and serine acetyltransferase from Trypanosoma J Biol Chem 276 6516-23. Jhee, K. H.; McPhie, P.; Miles, E. W. (2000) Yeast cystathionine beta-synthase is a pyridoxal phosphate enzyme but, unlike the human enzyme, is not a heme protein J Biol Chem 275 11541-4. Bukovska, G.; Kery, V.; Kraus, J. P. (1994) Expression of human cystathionine beta-synthase in Escherichia coli: purification and characterization Protein Expr Purif 5 442-8. Articles on 4.2.1.22 |
last changed |
2018/03/06 13:28 |
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