B6db families : 4_4_1

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4.4.1.11

Activity

4.4.1.11

Description

Methionine gamma-lyase.

Notes

Rather compact family composed of bacterial and protozoan sequences, strictly related to cystathionine gamma lyase (family 4.4.1.1) and other families of PLP-dependent enzymes acting on sulfurated amino acids.

PDB

1GC0;1E5F;

PLP Fold Type

PLP-dependent Domain

Domain alignment
Domain hmm

Fold type I

Number of sequences

Sequences in seed alignment

Bacteria

ZP_00043129 (Magnetococcus sp. MC-1); AAO46884 (Citrobacter freundii); NP_717420 (Shewanella oneidensis ); NP_904655 (Porphyromonas gingivalis W83); NP_972801 (Treponema denticola); NP_783053 (Clostridium tetani); NP_604313 (Fusobacterium nucleatum subsp. nucleatum ATCC 25586); ACB86020 (Natranaerobius thermophilus); MEGL_PSEPU (Pseudomonas putida); AAK25130 (Caulobacter crescentus CB15); ZP_00009970 (Rhodopseudomonas palustris);

Metazoa

BAC75878.1 (Entamoeba histolytica); BAC75877.1 (Entamoeba histolytica); CAA04124.1 (Trichomonas vaginalis); CAA04125 (Trichomonas vaginalis);

DISPLAY: Fasta format, alignment, hmm, hmm_local

Reference sequence

MEGL_PSEPU

Domain interval

11-395

Catalytic site

211 K

References

Fukamachi, H.; Nakano, Y.; Okano, S.; Shibata, Y.; Abiko, Y.; Yamashita, Y. (2005) High production of methyl mercaptan by L-methionine-alpha-deamino-gamma-mercaptomethane lyase from Treponema denticola Biochem Biophys Res Commun 331 127-31.

Manukhov, IV, Mamaeva, DV, Rastorguev, SM, Faleev, NG, Morozova, EA, Demidkina, TV, Zavilgelsky, GB. (2005) A gene encoding L-methionine gamma-lyase is present in Enterobacteriaceae family genomes: identification and characterization of Citrobacter freundii L-methionine gamma-lyase J Bacteriol 187 3889-93..

Tokoro, M.; Asai, T.; Kobayashi, S.; Takeuchi, T.; Nozaki, T. (2003) Identification and characterization of two isoenzymes of methionine gamma-lyase from Entamoeba histolytica: a key enzyme of sulfur-amino acid degradation in an anaerobic parasitic protist that lacks forward and reverse trans-sulfuration pathways J Biol Chem 278 42717-27..

Yoshimura, M.; Nakano, Y.; Yamashita, Y.; Oho, T.; Saito, T.; Koga, T. (2000) Formation of methyl mercaptan from L-methionine by Porphyromonas gingivalis Infect Immun 68 6912-6..

McKie, A. E.; Edlind, T.; Walker, J.; Mottram, J. C.; Coombs, G. H. (1998) The primitive protozoon Trichomonas vaginalis contains two methionine gamma-lyase genes that encode members of the gamma-family of pyridoxal 5'-phosphate-dependent enzymes J Biol Chem 273 5549-56..

Hori H, Takabayashi K, Orvis L, Carson DA, Nobori T. (1996) Gene cloning and characterization of Pseudomonas putida L-methionine-alpha-deamino-gamma-mercaptomethane-lyase Cancer Res 56 2116-22.

Articles on 4.4.1.11

last changed

2008/06/09 19:39