Activities | Families | Sequences | Fold types | References | Help
B6db families: 5.4.3.8

5.4.3.8
Activity 5.4.3.8
Description Glutamate-1-semialdehyde 2,1-aminomutase
Notes A very compact family of prokaryotic and plant enzymes.
PDB 2GSA;3GSB;4GSA;5HDM;
PLP Fold Type I
PLP-dependent Domain
Domain alignment
Domain hmm
Fold type I

Number of sequences
45
Sequences in seed alignment
ArchaeaGSA_AERPE (Aeropyrum pernix); GSA_METTH (Methanobacterium thermoautotrophicum); GSA_ARCFU (Archaeoglobus fulgidus); GSA_METJA (Methanococcus jannaschii); GSA_THEAC (Thermoplasma acidophilum); AAT42833 (Picrophilus torridus); AAK40528 (Sulfolobus solfataricus);
BacteriaGSA_PASMU (Pasteurella multocida); ZP_00122533 (Haemophilus somnus); GSA_VIBCH (Vibrio cholerae); GSA_SYNP6 (Synechococcus sp. (strain PCC 6301)); GSA_PSEAE (Pseudomonas aeruginosa); NP_923017 (Gloeobacter violaceus); GSA_CLOPE (Clostridium perfringens); GSA_MYCLE (Mycobacterium leprae); GSA_HELPJ (Helicobacter pylori J99); GSA_CAMJE (Campylobacter jejuni); GSA_STRCO (Streptomyces coelicolor); GSA_PROFR (Propionibacterium freudenreichii shermanii); GSA_BACHD (Bacillus halodurans); GSA_STAAU (Staphylococcus aureus); GSA_ECOLI (Escherichia coli); GSA_BACSU (Bacillus subtilis); GSA_XANCH (Xanthomonas campestris (pv. phaseoli)); GSA_SYNEL (Synechococcus elongatus); GSA_SALTY (Salmonella typhimurium); GSA_DEIRA (Deinococcus radiodurans); GSA_AQUAE (Aquifex aeolicus); ZP_00181408 (Moorella thermoacetica); GSA_NEIMB (Neisseria meningitidis (serogroup B)); GSA_XYLFA (Xylella fastidiosa); GSA_SYNY3 (Synechocystis sp. (strain PCC 6803)); NP_895124 (Prochlorococcus marinus); ZP_00223405 (Burkholderia cepacia); KFC02770 (Acinetobacter baumannii ATCC 19606);
ViridiplantaeGSA2_ARATH (Arabidopsis thaliana); AAO63783 (Brassica napus); AAN74531 (Polytomella sp.); GSA_LYCES (Lycopersicon esculentum); GSA1_ARATH (Arabidopsis thaliana); GSA_SOYBN (Glycine max); GSA_TOBAC (Nicotiana tabacum); GSA_CHLRE (Chlamydomonas reinhardtii); GSA_HORVU (Hordeum vulgare); GSA_ANASP (Nostoc sp.);

DISPLAY: Fasta format, alignment, hmm, hmm_local


Reference sequence GSA_SYNP6
Domain interval 42-368
Catalytic site 273 K
 
References
 Nardella C, Boi D, di Salvo ML, Barile A, Stetefeld J, Tramonti A, Contestabile R (2019) Isolation of a Complex Formed Between Acinetobacter baumannii HemA and HemL, Key Enzymes of Tetrapyrroles Biosynthesis Front Mol Biosci 6 6.

 Song Y, Pu H, Jiang T, Zhang L, Ouyang M (2016) Crystal structure of glutamate-1-semialdehyde-2,1-aminomutase from Arabidopsis thaliana Acta Crystallogr F Struct Biol Commun. 72 448-56.

 Schulze JO, Schubert WD, Moser J, Jahn D, Heinz DW. (2006) Evolutionary relationship between initial enzymes of tetrapyrrole biosynthesis J Mol Biol 358 1212-20.

 Atteia A, van Lis R, Beale SI. (2005) Enzymes of the heme biosynthetic pathway in the nonphotosynthetic alga Polytomella sp. Eukaryot Cell 4 2087-97.

 Tsang, E.W.; Hu Z.; Chang, Q.; McGregor, D.I.; Keller, W.A. (2003) Expression of a Brassica napus glutamate 1-semialdehyde aminotransferase in Escherichia coli and characterization of the recombinant protein Protein Expr Purif 29 193-201..

 Hennig, M.; Grimm, B.; Contestabile, R.; John, R. A.; Jansonius, J. N. (1997) Crystal structure of glutamate-1-semialdehyde aminomutase: an alpha2-dimeric vitamin B6-dependent enzyme with asymmetry in structure and active site reactivity Proc Natl Acad Sci U S A 94 4866-71.

 Palmieri, G.; Di Palo, M.; Scaloni, A.; Orru, S.; Marino, G.; Sannia, G. (1996) Glutamate-1-semialdehyde aminotransferase from Sulfolobus solfataricus Biochem J 320 541-5.

 Murakami, K.; Hashimoto, Y.; Murooka, Y. (1993) Cloning and characterization of the gene encoding glutamate 1-semialdehyde 2,1-aminomutase, which is involved in delta-aminolevulinic acid synthesis in Propionibacterium freudenreichii Appl Environ Microbiol 59 347-50.

 Murakami, K.; Korbsrisate, S.; Asahara, N.; Hashimoto, Y.; Murooka, Y. (1993) Cloning and characterization of the glutamate 1-semialdehyde aminomutase gene from Xanthomonas campestris pv. phaseoli Appl Microbiol Biotechnol 38 502-6..

 Sangwan, I.; O'Brian, M. R. (1993) Expression of the soybean (Glycine max) glutamate 1-semialdehyde aminotransferase gene in symbiotic root nodules Plant Physiol 102 829-34.

 Ilag, L. L.; Jahn, D.; Eggertsson, G.; Soll, D. (1991) The Escherichia coli hemL gene encodes glutamate 1-semialdehyde aminotransferase J Bacteriol 173 3408-13.

 Elliott, T.; Avissar, Y. J.; Rhie, G. E.; Beale, S. I. (1990) Cloning and sequence of the Salmonella typhimurium hemL gene and identification of the missing enzyme in hemL mutants as glutamate-1-semialdehyde aminotransferase J Bacteriol 172 7071-84.

 Grimm, B. (1990) Primary structure of a key enzyme in plant tetrapyrrole synthesis: glutamate 1-semialdehyde aminotransferase Proc Natl Acad Sci U S A 87 4169-73..

Articles on 5.4.3.8
last changed 2017/09/14 09:23

B6db families