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B6db families: bhcb

bhcb
Activity bhcb
Description Erythro-3-hydroxy-D-aspartate ammonia-lyase (4.3.1.-)
Notes Bacterial sequences, very similar to eukaryotic serine racemases (family 5.1.1.18) and to bacterial Threo-3-hydroxy-L-aspartate ammonia-lyases (family 4.3.1.16).
At least one enzyme in family 4.3.1.16 (from Pseudomonas sp. 99) also appears to catalyze quite efficiently the bhcB reaction.
PLP Fold Type II
PLP-dependent Domain
Domain alignment
Domain hmm
Fold type II

Reference sequence WP_041530430
Domain interval 20-308
Catalytic site 57 K
 
References
 Schada von Borzyskowski L, Severi F, Krüger K, Hermann L, Gilardet A, Sippel F, Pommerenke B, Claus P, Cortina NS, Glatter T, Zauner S, Zarzycki J, Fuchs BM, Bremer E, Maier UG, Amann RI, Erb TJ (2019) Marine Proteobacteria metabolize glycolate via the β-hydroxyaspartate cycle Nature 575 500-504.

 Nagano, H.; Shibano, K.; Matsumoto, Y.; Yokota, A.; Wada, M. (2017) Isolation and amino acid sequence of a dehydratase acting on d-erythro-3-hydroxyaspartate from Pseudomonas sp. N99, and its application in the production of optically active 3-hydroxyaspartate Biosci Biotechnol Biochem 81 1156-1164.

Articles on bhcb
last changed 2019/11/20 17:34

B6db families