B6db families : cobc

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cobc

Activity

Description

cobC-like proteins

Notes

A family of gene products, similar to CobC from Pseudomonas, apparently involved in the synthesis and addition of aminopropanol, in the cobalamin biosynthetic pathway.

The idea that these proteins are enzymes is strongly supported by the rigorous conservation of the PLP-binding lysine. However, the precise enzymatic function is unknown.

The family has been created because Christen and Mehta, in their reviews on the evolution of B6 enzymes, explicitly cited this group of gene products.

PLP Fold Type

PLP-dependent Domain

Domain alignment
Domain hmm

Fold type I

Number of sequences

Sequences in seed alignment

Bacteria

NP_643497 (Xanthomonas axonopodis pv. citri str. 306); NP_539623 (Brucella melitensis); CAD16100 (Ralstonia solanacearum); AAK88523 (Agrobacterium tumefaciens); CAC46523 (Sinorhizobium meliloti); ZP_00029105 (Burkholderia fungorum); AE004557_6 (Pseudomonas aeruginosa); COBC_PSEDE (Pseudomonas denitrificans); ZP_00051519 (Magnetospirillum magnetotacticum);

DISPLAY: Fasta format, alignment, hmm, hmm_local

Reference sequence

COBC_PSEDE

Domain interval

23-328

Catalytic site

199 K

References

Mehta, P. K.; Christen, P. (1993) Homology of pyridoxal-5'-phosphate-dependent aminotransferases with the cobC (cobalamin synthesis), nifS (nitrogen fixation), pabC (p- aminobenzoate synthesis) and malY (abolishing endogenous induction of the maltose system) gene products Eur J Biochem 211 373-6.

Articles on cobc

last changed

2009/07/06 16:31