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cqsa |
Activity |
cqsa |
Description |
Acyl-CoA:L-2-aminobutyrate C-acyltransferase (decarboxylating) (2.3.1.-) |
Notes |
A small family of bacterial enzymes, built based on the validated sequence from Vibrio cholerae. Sequences closely resembling bacterial serine C-palmitoyltransferases (family 2.3.1.50c) and 8-amino-7-oxononanoate synthases (2.3.1.47). |
PDB |
2WKA;2WK8; |
PLP Fold Type |
I |
PLP-dependent Domain |
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Number of sequences |
12 |
Sequences in seed alignment |
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Reference sequence |
NP_232914 |
Domain interval |
39-310 |
Catalytic site |
236 K |
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References |
Jahan N, Potter JA, Sheikh MA, Botting CH, Shirran SL, Westwood NJ, Taylor GL (2009) Insights into the Biosynthesis of the Vibrio cholerae Major Autoinducer CAI-1 from the Crystal Structure of the PLP-Dependent Enzyme CqsA J Mol Biol 393 763-73. Kelly RC, Bolitho ME, Higgins DA, Lu W, Ng WL, Jeffrey PD, Rabinowitz JD, Semmelhack MF, Hughson FM, Bassler BL. (2009) The Vibrio cholerae quorum-sensing autoinducer CAI-1: analysis of the biosynthetic enzyme CqsA Nat Chem Biol 5 891-5. Spirig T, Tiaden A, Kiefer P, Buchrieser C, Vorholt JA, Hilbi H. (2008) The Legionella autoinducer synthase LqsA produces an alpha-hydroxyketone signaling molecule J Biol Chem 283 18113-23. Articles on cqsa |
last changed |
2016/10/04 14:54 |
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