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B6db families: dhph-n

Activity dhph-n
Description 1-​amino-​2-​(phosphohydroxy)​ethyl​-phosphonate phospho-lyase (4.2.3.-)
Notes Small family, based on the validated DhpH sequence from Streptomyces luridus. The the C-terminal domain, responsible for the transpeptidase activity of these enzymes, has been removed from the sequences.
PLP Fold Type I
PLP-dependent Domain
Domain alignment
Domain hmm
Fold type I

Number of sequences 3
Sequences in seed alignment
BacteriaWP_051819677 (Streptomyces sp. NRRL S-920); WP_078870180 (Streptomyces sp. NRRL F-3213); ACZ13459 (Streptomyces luridus);

DISPLAY: Fasta format, alignment, hmm, hmm_local

Reference sequence ACZ13459
Domain interval 15-329
Catalytic site 187 K
 Bougioukou DJ, Mukherjee S, van der Donk WA (2013) Revisiting the biosynthesis of dehydrophos reveals a tRNA-dependent pathway Proc Natl Acad Sci U S A 110 10952-7.

Articles on dhph-n
last changed 2018/02/06 13:41

B6db families