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Activity

Description

L-Isoleucine-3-epimerase (5.1.1.-)

Notes

Proteins very similar to those in family 2.6.1.42 (branched-chain amino acid aminotransferases), but apparently devoid of aminotransferase activity.
Epimerase activity is conferred to these enzymes by a separate, small protein (termed DsaE in S. scopuliridis MfnH in S. drozdowiczii) which belongs to the NTF2_like superfamily and may be considered, in a sense, a cofactor for DsaD.

PLP Fold Type

PLP-dependent Domain

Domain alignment
Domain hmm

Fold type IV

Number of sequences

Sequences in seed alignment

Bacteria

WP_039632066 (Streptomyces sp. 769); WP_067639787 (Actinomadura latina); AJV88387 (Streptomyces drozdowiczii); WP_062332933 (Herbidospora sakaeratensis); ELS53321 (Streptomyces viridochromogenes Tue57); AJW76706 (Streptomyces scopuliridis);

DISPLAY: Fasta format, alignment, hmm, hmm_local

Reference sequence

AJW76706

Domain interval

70-308

Catalytic site

198 K

References

Li Q, Qin X, Liu J, Gui C, Wang B, Li J, Ju J (2016) Deciphering the biosynthetic origin of L-allo-isoleucine J Am Chem Soc 138 408-15.

Articles on dsad

last changed

2017/12/21 12:32