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B6db families: dsad

Activity dsad
Description L-Isoleucine-3-epimerase (5.1.1.-)
Notes Proteins very similar to those in family (branched-chain amino acid aminotransferases), but apparently devoid of aminotransferase activity.
Epimerase activity is conferred to these enzymes by a separate, small protein (termed DsaE in S. scopuliridis MfnH in S. drozdowiczii) which belongs to the NTF2_like superfamily and may be considered, in a sense, a cofactor for DsaD.
PLP Fold Type IV
PLP-dependent Domain
Domain alignment
Domain hmm
Fold type IV

Number of sequences 6
Sequences in seed alignment
BacteriaWP_039632066 (Streptomyces sp. 769); WP_067639787 (Actinomadura latina); AJV88387 (Streptomyces drozdowiczii); WP_062332933 (Herbidospora sakaeratensis); ELS53321 (Streptomyces viridochromogenes Tue57); AJW76706 (Streptomyces scopuliridis);

DISPLAY: Fasta format, alignment, hmm, hmm_local

Reference sequence AJW76706
Domain interval 70-308
Catalytic site 198 K
 Li Q, Qin X, Liu J, Gui C, Wang B, Li J, Ju J (2016) Deciphering the biosynthetic origin of L-allo-isoleucine J Am Chem Soc 138 408-15.

Articles on dsad
last changed 2017/12/21 12:32

B6db families