B6db families : l-lysine_2-aminotransferase

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l-lysine 2-aminotransferase

Activity

Description

L-lysine 2-aminotransferase (2.6.1.-)

Notes

Very small and homogeneous family, composed solely of sequences from Streptomycetes. The validated enzymes are involved in the biosynthesis of antibiotics such as virginiamycin S.

The family is phylogenetically related to a number of NDP-hexose aminotransferases, such as ArnB, TylB, 2.6.1.33 and perosamine aminotransferase.

PLP Fold Type

PLP-dependent Domain

Domain alignment
Domain hmm

Fold type I

Number of sequences

Sequences in seed alignment

Bacteria

CAA75797.1 (Streptomyces tendae); AF469950_1 (Streptomyces ansochromogenes); BAB83671.1 (Streptomyces virginiae);

DISPLAY: Fasta format, alignment, hmm, hmm_local

Reference sequence

CAA75797.1

Domain interval

19-404

Catalytic site

193 K

References

Namwat, W.; Kinoshita, H.; Nihira, T. (2002) Identification by heterologous expression and gene disruption of VisA as L-lysine 2-aminotransferase essential for virginiamycin S biosynthesis in Streptomyces virginiae J Bacteriol 184 4811-8..

Bruntner, C.; Bormann, C. (1998) The Streptomyces tendae Tu901 L-lysine 2-aminotransferase catalyzes the initial reaction in nikkomycin D biosynthesis Eur J Biochem 254 347-55..

Articles on l-lysine.2-aminotransferase

last changed

2008/10/24 10:35