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B6db families: lipk

Activity lipk
Description L-threonine--uridine -5-aldehyde transaldolase (2.2.1.-)
Notes Small family of bacterial enzymes, related to glycine hydroxymethyltransferase (family
PLP Fold Type I
PLP-dependent Domain
Domain alignment
Domain hmm
Fold type I

Reference sequence BAJ05887
Domain interval 11-387
Catalytic site 235 K
 Cui Z, Liu X, Overbay J, Cai W, Wang X, Lemke A, Wiegmann D, Niro G, Thorson JS, Ducho C, Van Lanen SG (2018) Enzymatic Synthesis of the Ribosylated Glycyl-Uridine Disaccharide Core of Peptidyl Nucleoside Antibiotics J Org Chem 83 7239-7249.

 Huang Y, Liu X, Cui Z, Wiegmann D, Niro G, Ducho C, Song Y, Yang Z, Van Lanen SG. (2018) Pyridoxal-5'-phosphate as an oxygenase cofactor: Discovery of a carboxamide-forming, alfa-amino acid monooxygenase-decarboxylase. Proc Natl Acad Sci U S A. 115 974-979.

 Funabashi M, Baba S, Takatsu T, Kizuka M, Ohata Y, Tanaka M, Nonaka K, Spork AP, Ducho C, Chen WC, Van Lanen SG (2013) Structure-based gene targeting discovery of sphaerimicin, a bacterial translocase I inhibitor Angew Chem Int Ed Engl 52 11607-11.

 Barnard-Britson, S,; Chi, X.; Nonaka, K.; Spork, A.P.; Tibrewal, N.; Goswami, A.; Pahari, P.; Ducho, C.; Rohr, J.; Van Lanen, S.G. (2012) Amalgamation of Nucleosides and Amino Acids in Antibiotic Biosynthesis: Discovery of an L-Threonine:Uridine-5'-Aldehyde Transaldolase J Am Chem Soc 134 18514-7.

Articles on lipk
last changed 2017/06/23 17:57

B6db families