B6db families : mcce

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mcce

Activity

Description

Microcin biosynthesis intermediate decarboxylase (4.1.1.-)

Notes

The only functionally validated protein with this activity is from E. coli. Its sequence is distantly related to 4.1.1.20, diaminopimelate decarboxylase.
Often but not always these sequences bear at the c-terminus an extra n-acetyltransferase domain. This domain itself seems dispensable for the aminopropylation reaction involving MccE, and has been removed from the sequences in this family (including the reference sequence).

PLP Fold Type

III

PLP-dependent Domain

Domain alignment
Domain hmm

Fold type III

Number of sequences

Sequences in seed alignment

Bacteria

ORM51437 (Pantoea brenneri); WP_059201098 (Serratia fonticola GS2); WP_011192342 (Yersinia pseudotuberculosis IP 32953); WP_012822362 (Pectobacterium parmentieri); WP_040264090 (Serratia symbiotica); WP_042820412 (Yersinia wautersii); ABW37145 (Escherichia coli); WP_044203009 (Pectobacterium carotovorum); ABB36236 (Synechococcus sp. CC9605); WP_000057510 (Salmonella enterica);

DISPLAY: Fasta format, alignment, hmm, hmm_local

Reference sequence

ABW37145

Domain interval

38-277

Catalytic site

62 K

References

Bantysh O, Serebryakova M, Makarova KS, Dubiley S, Datsenko KA, Severinov K (2014) Enzymatic synthesis of bioinformatically predicted microcin C-like compounds encoded by diverse bacteria MBio 5 e01059-14.

Kulikovsky A, Serebryakova M, Bantysh O, Metlitskaya A, Borukhov S, Severinov K, Dubiley S. (2014) The molecular mechanism of aminopropylation of peptide-nucleotide antibiotic microcin C J Am Chem Soc 136 11168-75.

Articles on mcce

last changed

2018/04/24 11:25