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B6db families: mocr

Activity mocr
Description mocR-like proteins
Notes The family is composed of bacterial proteins that act primarily as transcriptional regulators, but retain an intact aminotransferase domain.
Indeed, all MocR-like regulators exhibit a PLP attachment site with a conserved lysine residue.

In C. glutamicum, genetic data suggest that a protein of the MocR family functions as an aminotransferase in valine biosynthesis. The gene encoding this protein is located upstream of a potential operon of a newly described pyridoxine biosynthetic pathway and when disrupted, gives rise to a pyridoxine auxotrophy.

PDB 5X03;
PLP Fold Type I
PLP-dependent Domain
Domain alignment
Domain hmm
Fold type I

Number of sequences 22
Sequences in seed alignment
BacteriaAAG02195 (Streptomyces venezuelae); AAK25078 (Caulobacter crescentus); ZP_00053760 (Magnetospirillum magnetotacticum); CAB12197 (Bacillus subtilis); YCXD_BACSU (Bacillus subtilis); YP_011299 (Desulfovibrio vulgaris); ZP_00162162 (Anabaena variabilis); AAF01064 (Streptomyces venezuelae); NP_824604 (Streptomyces avermitilis); PTSJ_SALTY (Salmonella typhimurium); PDXR_CORGL (Corynebacterium glutamicum); YRDX_RHOSH (Rhodobacter sphaeroides); CAB12787 (Bacillus subtilis); AMR55826 (Ruegeria pomeroyi); ZP_00222078 (Burkholderia cepacia); MOCR_RHIME (Sinorhizobium meliloti); CAE42855 (Bordetella pertussis); WP_080573232 (Sinorhizobium meliloti); CAE37655 (Bordetella parapertussis); CABAH4382 (Brevibacillus brevis NBRC 100599); AAR33353 (Geobacter sulfurreducens); ZP_00311934 (Clostridium thermocellum);

DISPLAY: Fasta format, alignment, hmm, hmm_local

Reference sequence YCXD_BACSU
Domain interval 78-440
Catalytic site 286 K
 Schulz A, Stöveken N, Binzen IM, Hoffmann T, Heider J, Bremer E (2017) Feeding on compatible solutes: A substrate-induced pathway for uptake and catabolism of ectoines and its genetic control by EnuR Environ Microbiol 19 926-946.

 Tramonti A, Milano T, Nardella C, di Salvo ML, Pascarella S, Contestabile R (2017) Salmonella typhimurium PtsJ is a novel MocR-like transcriptional repressor involved in regulating the vitamin B6 salvage pathway FEBS J 284 466-484.

 Yu Q, Cai H, Zhang Y, He Y, Chen L, Merritt J, Zhang S, Dong Z (2017) Negative Regulation of Ectoine Uptake and Catabolism in Sinorhizobium meliloti: Characterization of the EhuR Gene J Bacteriol 199 e00119-16.

 Okuda K, Kato S, Ito T, Shiraki S, Kawase Y, Goto M, Kawashima S, Hemmi H, Fukada H, Yoshimura T. (2015) Role of the aminotransferase domain in Bacillus subtilis GabR, a pyridoxal 5'-phosphate-dependent transcriptional regulator Mol Microbiol 95 245-57.

 Takenaka T, Ito T, Miyahara I, Hemmi H, Yoshimura T (2015) A new member of MocR/GabR-type PLP-binding regulator of D-alanyl-D-alanine ligase in Brevibacillus brevis FEBS J 282 4201-17.

 Tramonti A, Fiascarelli A, Milano T, di Salvo ML, Nogués I, Pascarella S, Contestabile R (2015) Molecular mechanism of PdxR – a transcriptional activator involved in the regulation of vitamin B6 biosynthesis in the probiotic bacterium Bacillus clausii FEBS J 282 2966-84.

 Belitsky, B.R. (2004) Bacillus subtilis GabR, a Protein with DNA-binding and Aminotransferase Domains, is a PLP-dependent Transcriptional Regulator J Mol Biol 340 655-64.

 McHardy AC, Tauch A, Rückert C, Pühler A, Kalinowski J. (2003) Genome-based analysis of biosynthetic aminotransferase genes of Corynebacterium glutamicum J Biotechnol 104 229-40.

Articles on mocr
last changed 2017/10/26 14:42

B6db families